Results 51 to 60 of about 1,216,046 (262)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Dynamic Feature Selection for Clustering High Dimensional Data Streams

IEEE Access, 2019
Change in a data stream can occur at the concept level and at the feature level. Change at the feature level can occur if new, additional features appear in the stream or if the importance and relevance of a feature changes as the stream progresses. This
Conor Fahy, Shengxiang Yang
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Dating the break in high-dimensional data

Bernoulli, 2023
This paper is concerned with estimation and inference for the location of a change point in the mean of independent high-dimensional data. Our change point location estimator maximizes a new U-statistic based objective function, and its convergence rate and asymptotic distribution after suitable centering and normalization are obtained under mild ...
Wang, Runmin, Shao, Xiaofeng
openaire   +2 more sources

Evaluation of changes in prediction modelling in biomedicine using systematic reviews

BMC Medical Research Methodology
The number of prediction models proposed in the biomedical literature has been growing year on year. In the last few years there has been an increasing attention to the changes occurring in the prediction modeling landscape.
Lara Lusa, Franziska Kappenberg, Gary S. Collins, Matthias Schmid, Willi Sauerbrei, Jörg Rahnenführer, on behalf of the Topic Group for High-dimensional data of the STRATOS initiative   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Privacy-Preserving Data Sharing in High Dimensional Regression and Classification Settings

The Journal of Privacy and Confidentiality, 2012
We focus on the problem of multi-party data sharing in high dimensional data settings where the number of measured features (or the dimension) p is frequently much larger than the number of subjects (or the sample size) n, the so-called p >> n scenario ...
Stephen E. Fienberg, Jiashun Jin
doaj   +1 more source

Machine learning of high dimensional data on a noisy quantum processor

npj Quantum Information, 2021
Quantum kernel methods show promise for accelerating data analysis by efficiently learning relationships between input data points that have been encoded into an exponentially large Hilbert space.
Evan Peters, João Caldeira, Alan Ho, Stefan Leichenauer, Masoud Mohseni, Hartmut Neven, Panagiotis Spentzouris, Doug Strain, Gabriel N. Perdue   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Correlation based feature selection with clustering for high dimensional data

Journal of Electrical Systems and Information Technology, 2018
Feature selection is an essential technique to reduce the dimensionality problem in data mining task. Traditional feature selection algorithms are fail to scale on large space.
Smita Chormunge, Sudarson Jena
doaj   +1 more source