Results 81 to 90 of about 309,913 (283)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Exploration of the High Entropy Alloy Space as a Constraint Satisfaction Problem [PDF]

, 2017
High Entropy Alloys (HEAs), Multi-principal Component Alloys (MCA), or Compositionally Complex Alloys (CCAs) are alloys that contain multiple principal alloying elements. While many HEAs have been shown to have unique properties, their discovery has been
Abu-Odeh, Anas, Arroyave, Raymundo, Chen, Qing, Galvan, Edgar, Kirk, Tanner, Malak, Richard, Mao, Huahai, Mason, Paul   +7 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Mechanism-Guided Materials and Structural Design for High-Performance Nanogenerators

Nanoenergy Advances
The advancement of sensor systems that facilitate our daily lives relies on small, disposable batteries, which contribute to environmental pollution [...]
Ya Yang
doaj   +1 more source

Super-heavy fermion material as metallic refrigerant for adiabatic demagnetization cooling

, 2016
Low-temperature refrigeration is of crucial importance in fundamental research of condensed matter physics, as the investigations of fascinating quantum phenomena, such as superconductivity, superfluidity and quantum criticality, often require ...
Bud'ko, S. L., Canfield, P. C., Gegenwart, P., Jeevan, H. S., Piening, B., Tokiwa, Y.   +5 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Surface Nanostructuring of Copper Using Fluoride and Chloride

ChemElectroChem
Copper is an active electrocatalyst for various energy conversion reactions, but its performance depends on the structure of the active surface sites. In this work, we propose a simple strategy to tailor both the roughness and the active site's geometry ...
Vicente Pascual‐Llorens, Albert Serra Ramos, Pedro Mazaira‐Couce, María Escudero‐Escribano, Paula Sebastián‐Pascual   +4 more
doaj   +1 more source

Microstructure Dependence of Magnetic Properties for Al_1.5Fe₃Co₃Cr₁ Multi-Principal-Element Alloy

Metals
This study focuses on the microstructures and soft-magnetic properties of the Al1.5Fe3Co3Cr1 multi-principal-element alloy (MPEA) in different states. The MPEA was prepared using arc melting and suction-casting, followed by various heat treatments.
Shaoheng Sun, Yaxia Qiao, Hao Zhang, Dejun Tu, Guojun Wang, Zhenhua Wang, Qing Wang   +6 more
doaj   +1 more source

Magnetic stirling cycles: A new application for magnetic materials [PDF]

The elements of the cycle are summarized. The basic advantages include high entropy density in the magnetic material, completely reversible processes, convenient control of the entropy by the applied field, the feature that heat transfer is possible ...
Brown, G. V.
core   +1 more source