Results 51 to 60 of about 28,875 (249)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Regulatory Effectiveness in Algorithmic and High-Frequency Trading: A Critical Assessment [PDF]

ACTA VŠFS
Objective - Algorithmic and high-frequency trading have become a permanent fixture of modern financial markets over the past two decades — and regulators on both sides of the Atlantic have been trying to keep up, with mixed results.
JUKL, David, CVIK, Eva Daniela
doaj   +1 more source

The Random Walk of High Frequency Trading [PDF]

, 2014
This paper builds a model of high-frequency equity returns by separately modeling the dynamics of trade-time returns and trade arrivals. Our main contributions are threefold. First, we characterize the distributional behavior of high-frequency asset returns both in ordinary clock time and in trade time.
Eric M. Aldrich, Indra Heckenbach, Gregory Laughlin   +2 more
openaire   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Ecology of trading strategies in a forex market for limit and market orders.

PLoS ONE, 2018
There is a growing interest to understand financial markets as ecological systems, where the variety of trading strategies correspond to that of biological species.
Takumi Sueshige, Kiyoshi Kanazawa, Hideki Takayasu, Misako Takayasu   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Developing a High-Frequency Trading system with Dynamic Portfolio Management using Reinforcement Learning in Iran Stock Market [PDF]

تحقیقات مالی, 2018
Objective: Presence of the considerable gap between the time of receiving the buy/sell signals and the beginning of the price change trend provides an appropriate situation for implementation of algorithmic trading systems.
Mohammad Ali Rastegar, Mohsen Dastpak
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

High-Frequency Quantitative Trading of Digital Currencies Based on Fusion of Deep Reinforcement Learning Models with Evolutionary Strategies

Journal of Computing and Information Technology
High-frequency quantitative trading in the emerging digital currency market poses unique challenges due to the lack of established methods for extracting trading information.
Yijun He, Bo Xu, Xinpu Su
doaj   +1 more source