Results 81 to 90 of about 485,143 (293)

Is dementia incidence declining in high-income countries? A systematic review and meta-analysis

Clinical Epidemiology, 2018
Susanne Roehr,1,2,* Alexander Pabst,1,* Tobias Luck,3 Steffi G Riedel-Heller1 1Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany; 2LIFE – Leipzig Research Center for
Roehr S, Pabst A, Luck T, Riedel-Heller SG   +3 more
doaj  

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Pandemic preparedness and response: a survey among experts from high- and low-middle-income countries about the “100 Days Mission”

Frontiers in Public Health
BackgroundThe “100 Days Mission” (100DM), designed by the Coalition for Epidemic Preparedness Innovations (CEPI), represents an ambitious new concept in vaccine development for effective pandemic preparedness, rapid response, and the reduction of health ...
Vanessa Pencelli, Ralf Clemens, Mihai Alexandru Bica, Sue Ann Costa Clemens, Sue Ann Costa Clemens   +4 more
doaj   +1 more source

Impact of pneumococcal conjugate vaccines for children in high- and non–high-income countries

Expert Review of Vaccines, 2017
Introduction: The high level of effectiveness of pneumococcal conjugate vaccines (PCVs) was demonstrated initially in high-income countries (HICs). However, because the burden of pneumococcal diseases (PDs) is greater in non–high-income countries (NHICs)
Robert Cohen, Jérémie François Cohen, Martin Chalumeau, Corinne Levy   +3 more
doaj   +1 more source

P2451Epidemiology of heart failure in Australia: evidence of developing world hotspots in a high income country [PDF]

, 2017
S. Booley, Lingwei Chen, Ashley K. Keates, Alice David, C. Mainland, J. Harris, Simon Stewart   +6 more
openalex   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Greater increases in temperature extremes in low versus high income countries

Environmental Research Letters, 2017
It is commonly expected that the world’s lowest income countries will face some of the worst impacts of global warming, despite contributing the least to greenhouse gas emissions. Using global atmospheric reanalyses we show that the world’s lowest income
Nicholas Herold, Lisa Alexander, Donna Green, Markus Donat   +3 more
doaj   +1 more source

Achieving higher performing primary care through patient registration: A review of twelve high-income countries

, 2021
Gregory P. Marchildon, Shuli Brammli‐Greenberg, Mark Dayan, Antonio Giulio de Belvis, Coralie Gandré, David Isaksson, Madelon Kroneman, Stefan Neuner‐Jehle, Ingrid Sperre Saunes, Stephen Thomas, Karsten Vrangbæk, Wilm Quentin   +11 more
openalex   +2 more sources

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Enhanced Photocatalytic Wastewater Purification and Bacterial Elimination via Copper Ion Irradiation‐Induced Modification of BiOCl

Advanced Science, EarlyView.
This study presents a copper ion irradiation method to achieve the modification function of BiOCl. By using high‐energy ion beams to introduce impurity ions inside the material, the intrinsic electric field of BiOCl is optimized, promoting the separation of photogenerated carriers and enhancing the photocatalytic activity.
Sihan Ma, Dewang Cui, Jianglong Kong, Wentao Li, Zheng Han, Yipeng Li, Shidong Zhang, Xinglin Yu, Deng Long, Xue Bai, Lin Wang, Guang Ran, Zhijun Zhao   +12 more
wiley   +1 more source