Results 201 to 210 of about 12,153 (254)

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing

Advanced Science, EarlyView.
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos, Laia Bagur, Cristina Vaca, Aritz Lafuente, Joaquin Llacer‐Wintle, Bojan Ambrožič, Christina Stefani, Minsoo Kim, Goran Dražić, Darja Lisjak, Jordi Sort, Xiang‐Zhong Chen, Maria Jose Esplandiu, Salvador Pané, Carme Nogués, Josep Nogués, Andreu Blanquer, Borja Sepúlveda   +17 more
wiley   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

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Focal High-Intensity Focused Ultrasound Ablation of the Prostate

Journal of Endourology, 2021
With the advancement of early detection tools for prostate cancer and ability to better localize disease, there has been increased interest in focal or targeted therapies that carry less morbidity than traditional whole-gland treatments. The Sonablate ® high-intensity focused ultrasound (HIFU)
Lauren R, Abrams, Michael O, Koch, Clinton D, Bahler   +2 more
openaire   +2 more sources

High-intensity focused ultrasound ablation of breast cancer

Expert Review of Anticancer Therapy, 2007
The noninvasive ablation of tumors with high-intensity focused ultrasound (HIFU) energy has received increasingly widespread interest. The temperature within the focal volume of an ultrasound beam is rapidly raised to cytotoxic levels. HIFU can selectively ablate a targeted tumor at depth without any damage to surrounding or overlying tissues.
Feng, Wu, Gail, ter Haar, Wei R, Chen
openaire   +2 more sources

High-Intensity Focused Ultrasound Ablation by the Dual-Frequency Excitation

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2019
High-intensity focused ultrasound (HIFU) has emerged as an effective and noninvasive therapeutic modality for cancer and solid tumor. Despite its promising clinical outcomes and the approval of the Food and Drug Administration of many countries, the ablation time of a large target is long, so enhancement of the lesion production is highly desired.
Siu Kwun Berlinda Law, Yufeng Zhou
openaire   +3 more sources

Chronic Histological Transmurality of High-Intensity Focused Ultrasound Ablation

The Annals of Thoracic Surgery, 2012
We evaluated histologic results for surgical left maze with an high-intensity focused ultrasound (HIFU) energy source. Two patients came to our attention 6 and 48 months, respectively, after ablation concomitant to a valve procedure. Tissue specimens, obtained from the lesion site on the mitral isthmus and from the "box lesion" around the pulmonary ...
P. Vanelli, R. Rossi, G. Gelpi, G. Cagnoni, M. Contino, E. Bosisio, G. Vago, C. Antona   +7 more
openaire   +3 more sources

Enhancement of ultrasound contrast agent in High-Intensity focused ultrasound ablation

Advances in Therapy, 2006
High-intensity focused ultrasound (HIFU) is becoming an increasingly attractive modality for ablation. Enhancement of HIFU is an important issue that has been discussed and investigated worldwide. Ultrasound contrast agents are considered to constitute an efficient medium for changing acoustic characteristics and improving energy deposition in the ...
Wen, Luo, Xiaodong, Zhou, Xue, Tian, Xialong, Ren, Minjuan, Zheng, Kejun, Gu, Guangbin, He   +6 more
openaire   +2 more sources

High-Intensity Focused Ultrasound Ablation Therapy of Gliomas

2018
Ultrasound in clinical medicine is most commonly associated with imaging, but can be harnessed to yield an array of biological effects, including thermal ablation of brain tumors. Therapeutic ultrasound has been studied for many years, but only within the last decade has the technology reached a point where it is safe and practical for clinical ...
Ryan D, Alkins, Todd G, Mainprize
openaire   +2 more sources

Ablation of tissue volumes using high intensity focused ultrasound

Ultrasound in Medicine & Biology, 1996
Successful application of high intensity focused ultrasound to cancer treatment requires complete ablation of tissue volumes. In order to destroy an entire tumour it is necessary to place a contiguous array of touching lesions throughout it. In a study of how best to achieve this, exposures were selected to give single lesions that were thermal in ...
A L, Malcolm, G R, ter Haar
openaire   +2 more sources