Results 181 to 190 of about 31,117 (298)

MPAT: Modular Petri Net Assembly Toolkit. [PDF]

SoftwareX
Chiaradonna S, Jevtić P, Sterner B.
europepmc   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Comparing Care Pathways Between COVID-19 Pandemic Waves Using Electronic Health Records: A Process Mining Case Study. [PDF]

J Healthc Inform Res
Georgiev K, Fleuriot JD, Papapanagiotou P, McPeake J, Shenkin SD, Anand A.   +5 more
europepmc   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Boolean matrix logic programming for active learning of gene functions in genome-scale metabolic network models. [PDF]

Mach Learn
Ai L, Muggleton SH, Liang SS, Baldwin GS.   +3 more
europepmc   +1 more source

Tailoring Multifunctional Carbon Dots via Precursor Stoichiometry: Switching Between Solid‐State Fluorescence and Broadband Absorption Through Aggregation Control

Advanced Science, EarlyView.
Precursor stoichiometry programs the surface chemistry of carbon dots, directing their self‐assembly into distinct aggregation modes. Aldehyde‐enriched surfaces form ordered, hydrogen‐bonded assemblies that enable bright red solid‐state fluorescence, whereas amine‐rich surfaces promote compact π–π stacked aggregates with broadband visible‐light ...
Gaixia Yang, Hao Sun, Defa Hou, Fulin Yang, Yuan Zou, Bei Zhou, Lanxiang Liu, Xu Lin, Guanben Du   +8 more
wiley   +1 more source

Prolonged intermittent theta burst stimulation enhances hippocampal plasticity via GluN2A-mediated signaling. [PDF]

Front Aging Neurosci
Popovic D, Zaric Kontic M, Zeljkovic Jovanovic M, Milosevic M, Martic T, Radukic T, Stekic A, Glavonic E, Jakovljevic A, Mihajlovic K, Adzic Bukvic M, Stevanovic I, Dragic M.   +12 more
europepmc   +1 more source

High‐Yield Fabrication of Electrolyte‐Gated Transistors Based on Graphene Acetic Acid

Advanced Electronic Materials, EarlyView.
We fabricated a liquid‐gated transistor based on graphene acetic acid, which is dielectrophoretically deposited, featuring a spatial resolution down to 10 microns. Our method enables a versatile and reproducible fabrication featuring state‐of‐the‐art performance.
Georgian Giani Ilie, Lara Franchin, Ludovica Pradetto Battel, Stefano Bonaldo, Alessandro Paccagnella, Biagio di Vizio, Stefano Agnoli, Rafael C. Hensel, Antonio Gaetano Ricciardulli, Simone Battiston, Mauro Sambi, Francesco Sedona, Paolo Samorì, Stefano Casalini   +13 more
wiley   +1 more source

NETs accelerate aortic valve calcification by promoting M1 macrophage polarization through the TLR9 signaling pathway. [PDF]

Mol Cell Biochem
Liu L, Lan Z, Liu X, Chen Y, Chen Z, Cheng L, Hu T.   +6 more
europepmc   +1 more source

Surface Energy Modulated Self‐Assembly of Percolative Gallium Nanodroplet Films for Stretchable Electronics

Advanced Electronic Materials, EarlyView.
Surface‐energy guided self‐assembly of liquid metals enables the transformation of liquid metal micro/nanodroplets into continuous perocolative films on elastomeric substrates. By tailoring interfacial energetics and wetting behavior, uniform, conductive, and stretchable films are achieved, offering scalable pathways for high‐performance soft ...
Alwar Samy Ramasamy, Gayatri Subhalaxmi, Sneha Banerjee, Mark Vailshery, Renu Raman Sahu, Sivakumar K.S, Ajisha Chathyattu, Tapajyoti Das Gupta   +7 more
wiley   +1 more source