Results 41 to 50 of about 21,375,197 (296)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Graphical Approach for Hybrid Simulation of 3D Diffusion Bio-Models via Coloured Hybrid Petri Nets

Modelling and Simulation in Engineering, 2020
Three-dimensional modelling of biological systems is imperative to study the behaviour of dynamic systems that require the analysis of how their components interact in space. However, there are only a few formal tools that offer a convenient modelling of
Amr Ismail, Mostafa Herajy, Elsayed Atlam, Monika Heiner   +3 more
doaj   +1 more source

Multi-Event Modeling and Recognition Using Extended Petri Nets

IEEE Access, 2020
This paper addresses the event modeling and recognition problem in video surveillance systems using the system net on the Petri Net (PN) formalism. The single event on the foundation of prior knowledge is first modeled via arranging event schemes from ...
Ji Qiu, Lide Wang, Yin Wang, Yu Hen Hu
doaj   +1 more source

Towards Reachability Trees for High-level Petri Nets

DAIMI Report Series, 1985
<p>High-level Petri nets have been introduced as a powerful net type, by which it is possible to handle rather complex systems in a succinct and manageable way. The success of high-level Petri nets is undebatable when we speak about description, but there is still much work to be done to establish the necessary analysis methods.
Huber, Peter, Jensen, Arne M., Jepsen, Leif O., Jensen, Kurt   +3 more
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Impact of Petri Nets on System-of-Systems Engineering [PDF]

, 2009
The successful engineering of a large-scale system-of-systems project towards deterministic behaviour depends on integrating autonomous components using international communications standards in accordance with dynamic requirements.
SINCLAIR, KIRSTEN,MHAIRI
core  

Development and Evaluation of a Novel Investment Decision System in Cryptocurrency Market

Applied Artificial Intelligence, 2021
More and more people are entering the cryptocurrency market after Bitcoin (BTC) soared to nearly USD 20,000 in 2017. To promote the development of information technology and cryptocurrency marketing, various computerized systems integrating information ...
Dai-Lun Chiang, Sheng-Kuan Wang, Yi-Nan Lin, Cheng-Ying Yang, Victor R.L. Shen, Tony Tong-Ying Juang, Ting-Yi Liao   +6 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Modeling and Control Design Based on Petri Nets Tool for a Serial Three-Phase Five-Level Multicellular Inverter Used as a Shunt Active Power Filter

Energies, 2021
In this work, we represent a shunt active power filter (SAPF) based on a serial three-phase flying capacitor multilevel inverter (FCMI) controlled by a Petri Nets representation (PNs). This structure is chosen for its significant performances.
Sana Othman, Mohamad Alaaeddin Alali, Lassaad Sbita, Jean-Pierre Barbot, Malek Ghanes   +4 more
doaj   +1 more source