Results 241 to 250 of about 1,116,097 (338)

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

open access: yesAdvanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi   +16 more
wiley   +1 more source

Development and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease

open access: yesAdvanced Science, EarlyView.
This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.
Lushan Xiao   +14 more
wiley   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

open access: yesAdvanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian   +18 more
wiley   +1 more source

Educational Needs in Geriatric Medicine Among Health Care Professionals and Medical Students in COST Action 21122 PROGRAMMING: Mixed-Methods Survey Protocol.

open access: yesJMIR Res Protoc
Ogliari G   +22 more
europepmc   +1 more source

Autotuning in an Array Processing Language using High-level Program Transformations

open access: gold, 2011
Yusuke Shirota   +3 more
openalex   +1 more source

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