Results 271 to 280 of about 1,116,097 (338)

Topological Scaffold‐Based Trispecific Recombinant Protein‐Drug Conjugates for Solid Tumor Eradication

open access: yesAdvanced Science, EarlyView.
A novel tri‐specific recombinant protein and its drug conjugate are developed, named sRP‐EHI and sRPDC‐EHI, which feature a star‐shaped topological structure. It can simultaneously bind the EGFR, HER2, and integrin αvβ3 overexpressed in cancer cells.
Huiyi Jiang   +6 more
wiley   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

open access: yesAdvanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu   +14 more
wiley   +1 more source

Irisin‐Loaded Cerium‐Containing Mesoporous Bioactive Glass for Effective Immunomodulation and Odontogenesis of Dental Pulp Cells

open access: yesAdvanced Science, EarlyView.
The Irisin/Ce‐MBGNs delivery system can slowly release myokine Irisin for vital pulp therapy. Irisin/Ce‐MBGNs can enhance mitochondrial function and promote the differentiation of inflammatory macrophages toward M2‐Mφ, thereby regulating the immune response mechanism of inflamed dental pulp.
Mingxin Wang   +9 more
wiley   +1 more source

Code generation system based on MDA and convolutional neural networks. [PDF]

open access: yesFront Artif Intell
Vargas-Monroy G   +4 more
europepmc   +1 more source

Code Coverage Analysis for Concurrent Programming Languages Using High-Level Decision Diagrams

open access: green, 2009
Maksim Jenihhin   +4 more
openalex   +1 more source

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