Results 31 to 40 of about 3,164,376 (236)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

BIF : a behavioral intermediate format for high level synthesis [PDF]

, 1989
This report describes a new intermediate format for behavioral synthesis systems, based on annotated state tables. It supports user control of the synthesis process by allowing specification of partial design structures, user-bindings and user ...
Dutt, Nikil D., Gajski, Daniel D., Hadley, Tedd   +2 more
core   +1 more source

Advanced Datapath Synthesis using Graph Isomorphism

, 2017
This paper presents an advanced DAG-based algorithm for datapath synthesis that targets area minimization using logic-level resource sharing. The problem of identifying common specification logic is formulated using unweighted graph isomorphism problem ...
Choudhury, Mihir, Ciesielski, Maciej, Sullivan, Andrew, Yu, Cunxi   +3 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Study of combining GPU/FPGA accelerators for high-performance computing [PDF]

, 2013
This contribution presents the performance modeling of a super desktop with GPU and FPGA accelerators, using OpenCL for the GPU and a high-level synthesis compiler for the FPGAs.
Braeken, An, Cornelis, Jan G, D'Hollander, Erik, da Silva Gomes, Bruno, Lemeire, Jan, Touhafi, Abdellah   +5 more
core   +1 more source

SqueezeJet: High-level Synthesis Accelerator Design for Deep Convolutional Neural Networks

, 2018
Deep convolutional neural networks have dominated the pattern recognition scene by providing much more accurate solutions in computer vision problems such as object recognition and object detection.
Mousouliotis, Panagiotis G., Petrou, Loukas P.   +1 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

High-Level Synthesis of Benevolent Trojans [PDF]

2019 Design, Automation & Test in Europe Conference & Exhibition (DATE), 2019
High-Level Synthesis (HLS) allows designers to create a register transfer level (RTL) description of a digital circuit starting from its high-level specification (e.g., C/C++/SystemC). HLS reduces engineering effort and design-time errors, allowing the integration of additional features. This study introduces an approach to generate benevolent Hardware
Pilato, Christian, Basu, Kanad, Shayan, Mohammed, Regazzoni, Francesco, Karri, Ramesh   +4 more
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source