Results 81 to 90 of about 3,164,376 (236)
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Hierarchical agent supervision [PDF]
, 2018 Agent supervision is a form of control/customization where a supervisor restricts the behavior of an agent to enforce certain requirements, while leaving the agent as much autonomy as possible.
Banihashemi, Bita +2 more
core
A Theory of Formal Synthesis via Inductive Learning
, 2016 Formal synthesis is the process of generating a program satisfying a high-level formal specification. In recent times, effective formal synthesis methods have been proposed based on the use of inductive learning.
Jha, Susmit, Seshia, Sanjit A.
core +2 more sources
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Markedly different ATP requirements for rRNA synthesis and mtDNA light strand transcription versus mRNA synthesis in isolated human mitochondria [PDF]
, 1987 In isolated mitochondria from HeLa cells, the ATP requirements for mitochondral DNA (mtDNA) transcription and RNA processing can be satisfied by either endogenous synthesis, mainly through oxidative- phosphorylation, or by exogenous supply.
Attardi, Giuseppe +2 more
core
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Program Analysis and Source-Level Communication Optimizations for High-Level Synthesis [PDF]
, 2011 The use of hardware accelerators, e.g., with GPGPUs or customized circuits using FPGAs, are particularly interesting for accelerating data- and compute-intensive applications.
Alias, Christophe +2 more
core +2 more sources
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Synthesis from specifications : basic concepts [PDF]
, 1990 The need has evolved for a synthesis tool at the computer system level. SpecSyn is one such tool. Basically, it will view the world as a set of chips communicating via protocols.
Gajski, Daniel D. +2 more
core
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source