Results 71 to 80 of about 4,365,462 (264)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

On High Order Estimates in QED

open access: yesPhysics Letters B, 1977
In this note it is pointed out that there are single gauge invariant diagrams contributing to the leptonic g − 2 for which the amplitude grows like n ! in the n 'th order. The leading asymptotic behaviour is estimated.
openaire   +1 more source

High-order pulse front tilt caused by high-order angular dispersion

open access: yesOptics Express, 2003
We have found general expressions relating the high-order pulse front tilt and the high-order angular dispersion in an ultrashort pulse, for the first time to our knowledge. The general formulae based on Fermat's principle are applicable for any ultrashort pulse with angular dispersion in the limit of geometrical optics. By virtue of these formulae, we
Yasuo, Nabekawa, Katsumi, Midorikawa
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modeling Higher-Order Interactions in Graphs Through Combinatorial Arc-Transitive Structure Using Graph Convolutional Network

open access: yesIEEE Access
The analysis of networks, including social, citation, biological, and traffic networks, has become a critical research area, enabling deeper insights into complex systems across diverse fields.
Qingwei Wen
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

CDR-Solv: Solving the Convection-Diffusion-Reaction Equation with Algebraic Sub-Grid Scale Stabilization Using Python

open access: yesApplied Sciences
The convection-diffusion-reaction (CDR) equation is a fundamental mathematical model for simulating the transport of pollutants. It is a crucial tool for addressing global environmental challenges.
Ángel P. Villota-Cadena   +3 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Heat Pump Optimization—Comparative Study of Different Optimization Algorithms and Heat Exchanger Area Approximations

open access: yesEnergies
More energy efficient heat pumps can be designed if the industry is able to identify reliable optimization schemes able to predict how a fixed amount of money is best spent on the different individual components.
Eivind Brodal
doaj   +1 more source

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