Results 121 to 130 of about 612,057 (317)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The thallium magic cluster on Si(111)-7x7

, 2007
1
황춘규, 김남동, 김재삼, 이근식, 정진욱   +4 more
core  

Mixed language high-performance computing for plasma simulations [PDF]

, 2003
Java is receiving increasing attention as the most popular platform for distributed computing. However, programmers are still reluctant to embrace Java as a tool for writing scientific and engineering applications due to its still noticeable performance
Getov, Vladimir, Lu, Q.
core  

Algorithms for High-Performance State-Machine Replication

, 2019
Aktualisierung der zweiten Seite der Dissertation: Vervollständigung der GutachterMany distributed systems require coordination between the servers involved.
Poke, Marius
core   +1 more source

High-performance ensembles of online sequential extreme learning machine for regression and time series forecasting

, 2020
Ensembles of Online Sequential Extreme Learning Machine algorithm are suitable for forecasting Data Streams with Concept Drifts. Nevertheless, data streams forecasting require high-performance implementations due to the high incoming samples rate.
Gradvohl, André Leon S., Grim, Luís Fernando L.   +1 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Prediction of mutation-induced protein stability changes based on the geometric representations learned by a self-supervised method

BMC Bioinformatics
Background Thermostability is a fundamental property of proteins to maintain their biological functions. Predicting protein stability changes upon mutation is important for our understanding protein structure–function relationship, and is also of great ...
Shan Shan Li, Zhao Ming Liu, Jiao Li, Yi Bo Ma, Ze Yuan Dong, Jun Wei Hou, Fu Jie Shen, Wei Bu Wang, Qi Ming Li, Ji Guo Su   +9 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A grid computing framework for commercial simulation packages

, 2007
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.An increased need for collaborative research among different organizations, together with continuing advances in communication technology and computer ...
Mustafee, Navonil
core