Results 151 to 160 of about 612,057 (317)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Exploring Scientific Application Performance Using Large Scale Object Storage
, 2018 One of the major performance and scalability bottlenecks in large scientific applications is parallel reading and writing to supercomputer I/O systems. The usage of parallel file systems and consistency requirements of POSIX, that all the traditional HPC
Sai Narasimhamurthy +9 more
core +1 more source
Bioinformatics and High-Performance Computing Methods for Deciphering and Fighting COVID-19-Editorial. [PDF]
BioTech (Basel), 2022 Cannataro M, Agapito G.
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2020 Includes bibliographical references and index."This book examines crowd-based software engineering. It explores effective solutions, automation supports, and case studies about crowd-based software engineering"--Chapter 1.
Gupta Varun
core
Retracted: Dynamic Mechanism and Decision Analysis of Urban Exhibition Tourism Development Based on High-Performance Computing. [PDF]
Comput Intell Neurosci, 2023 Intelligence And Neuroscience C.
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Retrievium – A Semantic Repository for Quantum Mechanical Structures
Performing quantum mechanical calculations at high levels of theory is computationally expensive, but often identical calculations have to be repeated by other researchers because they don't have access to the results of already completed jobs.
core
COVID-19 Detection using adopted convolutional neural networks and high-performance computing. [PDF]
Multimed Tools Appl, 2023 Singh AK, Kumar A, Kumar V, Prakash S.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source