Results 191 to 200 of about 612,057 (317)

MorphoCloud: Democratizing Access to High-Performance Computing for Morphological Data Analysis. [PDF]

F1000Res
Maga AM, Fillion-Robin JC.
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Robust and compact reversible logic gate for low-power and high-performance computing. [PDF]

Sci Rep
Rajput A, Kumawat R, Srinivasulu A, Sharma J.   +3 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A scalable automated framework for multiply-accumulate unit design in high-performance computing applications. [PDF]

Sci Rep
Venkatachalam A, Seerengasamy U, Ponraj AS.   +2 more
europepmc   +1 more source

A Parallelization Strategy for the Time Efficient Analysis of Thousands of LC/MS Runs in High-Performance Computing Environment. [PDF]

J Proteome Res, 2022
van Zalm P, Viodé A, Smolen K, Fatou B, Hayati AN, Schlaffner CN, Levy O, Steen J, Steen H.   +8 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

State of the Art in Parallel Computing with R

R is a mature open-source programming language for statistical computing and graphics. Many areas of statistical research are experiencing rapid growth in the size of data sets. Methodological advances drive increased use of simulations.
Hao Yu, Martin Morgan, Markus Schmidberger, Ulrich Mansmann, Luke Tierney, Dirk Eddelbuettel   +5 more
core  

Ten simple rules for building and maintaining sustainable high-performance computing infrastructure for research in resource-limited settings. [PDF]

PLoS Comput Biol
Galiwango R, Whalen CJ, Kebirungi G, Atwine MT, Kimera R, Ssekagiri A, Kimbowa TW, Lukyamuzi E, Nsubuga M, eLwazi ODSP, Ssentongo L, Mutegeki H, Fonner JM, Wuerthwein F, Berman A, Okalebo LB, McCarthy M, Kramer VS, Quinones M, Cruz P, Hurt D, Giovanni MY, Mulder N, Tartakovsky M, Kayondo J, Jjingo D.   +25 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source