Results 251 to 260 of about 317,795 (294)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

open access: yesFEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar   +3 more
wiley   +1 more source

HIGH-PERFORMANCE COMPUTING MEETS HIGH-PERFORMANCE MEDICINE

Biocomputing 2023, 2022
The following sections are included: Introduction, Background, and Motivation, Workshop Presenters, References.
Anurag, Verma   +3 more
openaire   +2 more sources

Trends in high - performance computing

IEEE Circuits and Devices Magazine, 2004
The Annual Boole Lecture was established and is sponsored by the Boole Centre for Research in Informatics, the Cork Constraint Computation Centre, the Department of Computer Science, and the School of Mathematics, Applied Mathematics and Statistics at University College Cork.
openaire   +1 more source

High performance horizons [high performance computing]

Computing and Control Engineering, 2004
The field of high performance computing is undergoing a lot of changes. At the low end, supercomputers are becoming ever more affordable while, at the high end, it is becoming increasingly difficult to exploit the full potential of the most advanced hardware, given the sheer scale of the software challenges involved.
openaire   +1 more source

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