Results 171 to 180 of about 240,885 (306)

Atroposelective Construction of Axially Chiral Tetraarylethenes Via NHC‐Catalyzed Desymmetrization

open access: yesAdvanced Science, EarlyView.
We report the first NHC‐catalyzed atroposelective synthesis of axially chiral TAEs via oxidative desymmetrization of prochiral TAE dialdehydes. This catalytic strategy operates under mild conditions and accommodates a broad range of phenolic and nitrogen nucleophiles, delivering diverse axially chiral TAEs in good yields and up to 99% ee.
Yang‐Ze Zheng   +6 more
wiley   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

open access: yesAdvanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo   +11 more
wiley   +1 more source

Removal of Emerging Contaminants (Endocrine Disruptors) Using a Photocatalyst and Detection by High-Performance Liquid Chromatography (HPLC). [PDF]

open access: yesInt J Environ Res Public Health
Santos MS   +7 more
europepmc   +1 more source

Cobalt Single‐Atom Catalysts for Ultrafast Sulfamethoxazole Degradation: Unveiling the Chloride‐Ion‐Enhanced Formation of Co(IV)=O

open access: yesAdvanced Science, EarlyView.
An atomically dispersed Co–N4 single‐atom catalyst rapidly activates peroxymonosulfate to remove the antibiotic sulfamethoxazole from water. Common ions have little impact, but chloride dramatically speeds degradation by promoting a high‐valent Co(IV) = O oxidant via in situ HOCl–catalyst electron transfer.
Anting Ding   +6 more
wiley   +1 more source

Determination of arylamine compounds in waste water using solid-phase extraction and reversed-phase high performance liquid chromatography

open access: yes, 1998
A simple, rapid, and sensitive method for determining 10 arylamine compounds in wastewater sample using solid-phase extraction (SPE) and high performance liquid chromatography (HPLC) with UV detection is developed.
Zhao, SL, Zou, HF, Xu, XB, Wei, FS
core  

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma   +12 more
wiley   +1 more source

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