Results 191 to 200 of about 852,877 (303)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Potential of Sentinel-3 snow cover fraction data for improving hydrological simulations at the regional scale. [PDF]

Sci Rep
Tanhapour M, Parajka J, Schwaizer G, Vreugdenhil M, Kohnová S, Hlavčová K, Výleta R, Szolgay J.   +7 more
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

High-resolution microclimatic grids for the Bohemian Forest Ecosystem based on in situ measurements. [PDF]

Sci Data
Brůna J, Macek M, Man M, Hederová L, Klinerová T, Moudrý V, Heurich M, Červenka J, Wild J, Kopecký M.   +9 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Uncertainty aware hybrid learning framework for fast and safe charging of lithium-ion batteries using multi-fidelity observers. [PDF]

Sci Rep
Parimala CHH, Varma PS, Kumar RS, Singh AR, Mohapatra B, Addis HK.   +5 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A satellite based machine learning approach for estimating high resolution daily average air temperature in a megacity in Brazil. [PDF]

Sci Rep
Roca-Barceló A, Schneider R, Pirani M, Sebastianelli A, Piel FB, Vineis P, Nardocci AC, Fecht D.   +7 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Extracellular space diffusion modelling identifies distinct functional advantages of glutamatergic and GABAergic synapse geometries. [PDF]

Fluids Barriers CNS
Gimenez P, Shakya RT, Santamaria F, Tønnesen J.   +3 more
europepmc   +1 more source