Results 321 to 330 of about 3,042,424 (374)

Pharmacokinetics of betamethasone in pre‐eclampsia: An in vivo and ex vivo study

British Journal of Clinical Pharmacology, EarlyView.
Aims To enhance understanding of betamethasone and its metabolites' pharmacokinetics in pregnancy, specifically early‐onset pre‐eclampsia, through a population pharmacokinetic model. Additionally, to investigate the placental metabolism and transfer of betamethasone and its main metabolites.
Sam Schoenmakers, Letao Li, Anna C. M. Kluivers, Michelle Broekhuizen, Madhavi S. Harhangi, A. H. Jan Danser, Irwin Reiss, Karel Allegaert, Sjoerd A. A. van den Berg, Bertrand D. van Zelst, Ron H. N. van Schaik, Philip L. J. DeKoninck, Emma Ronde, Sebastiaan D. T. Sassen, Sinno H. P. Simons, Birgit C. P. Koch   +15 more
wiley   +1 more source

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +1 more source

First‐time cefuroxime target tissue concentrations in long‐lasting spine surgery: Continuous evaluation after repeated weight‐dosed administrations

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Antimicrobial prophylaxis is central in preventing postoperative spine infections, yet knowledge on clinical target spine tissue concentrations remain limited. Current dosing regimens often involve fixed doses based on empirical knowledge, surrogate measures, non‐clinical evidence and methodology of variying quality.
Magnus Andreas Hvistendahl, Mats Bue, Pelle Hanberg, Sara Kousgaard Tøstesen, Sofus Vittrup, Maiken Stilling, Kristian Høy   +6 more
wiley   +1 more source

Analysis of 4616 clinical trial initial submissions received by the Medicines and Healthcare products Regulatory Agency between February 2019 and October 2023

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse clinical trial initial submissions received by the MHRA between February 2019 and October 2023. Methods Data on submissions were extracted from the clinical trials unit data bank. The primary end‐point was the type of clinical trial initial submissions.
Andrea Manfrin, Kingyin Lee, James Pound, Munir Pirmohamed, June Raine   +4 more
wiley   +1 more source

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High-Risk Pregnancy

Nursing Clinics of North America, 2018
Any unexpected or unanticipated medical or obstetric condition associated with a pregnancy with an actual or potential hazard to the health or well-being of the mother or fetus is considered a high-risk pregnancy. There is no exact definition of risk in pregnancy, as risk may be perceived in different ways by the woman and her health care provider ...
Nola A Holness
semanticscholar   +5 more sources

Is a Surrogate Pregnancy a High-Risk Pregnancy?

Obstetrical & Gynecological Survey, 2021
Importance As assisted reproductive technology has advanced, there has been an increase in gestational carriers/surrogate pregnancies. Information is needed to determine if these pregnancies are high-risk pregnancies and should be managed by maternal fetal medicine or if they are not high risk and should be cared for by ...
Everett F. Magann, Jack H. Klausen, Julie R Whittington, Patricia Amorado, Amy M. Phillips, Dean M. Moutos, Dawn S. Hughes   +6 more
openaire   +3 more sources

Relationship between melatonin and high-risk pregnancy: A review of investigations published between the years 2010 and 2020

Chronobiology International, 2021
The purpose of this review was to search for articles on human studies investigating the relationship between melatonin and high-risk pregnancy. An electronic search was conducted in the MEDLINE and PubMed databases from September 2010 to October 2020 ...
G. Laste, André Anjos da Silva, Brenda Rodrigues Gheno, Patricia Rychcik   +3 more
semanticscholar   +1 more source

Hospitalisation in high-risk pregnancy patients: is prenatal attachment affected?

Journal of Reproductive and Infant Psychology, 2020
Objective: To compare prenatal attachment in women hospitalised due to high-risk pregnancy with prenatal attachment in non-hospitalised patients. To describe the impact of social support, socio-demographic factors and the nature of the pregnancy on ...
Elisa Palma, I. Armijo, J. Cifuentes, Sergio Ambiado, P. Rochet, Blanca Díaz, J. Gutiérrez, Constanza Mena   +7 more
semanticscholar   +1 more source

Pregnant Women’s Experiences of the Conditions Affecting Marital Well-Being in High-Risk Pregnancy: A Qualitative Study

International Journal of Community Based Nursing and Midwifery, 2020
Background: High-risk pregnancy is associated with many problems which can affect marital well-being as well as maternal and fetal health. Yet, there is limited information about the conditions which affect marital well-being in high-risk pregnancy. This
K. mirzakhani, T. Khadivzadeh, F. Faridhosseini, A. Ebadi   +3 more
semanticscholar   +1 more source

A longitudinal study on high risk pregnancy and its outcome among antenatal women attending rural primary health centre in Puducherry, South India

Journal of Education and Health Promotion, 2019
BACKGROUND: Almost 15% of all pregnant women can develop potentially life-threatening complications. As a result, identification of high-risk pregnancy at earliest stage will be useful in directing appropriate intervention.
MarieGilbert Majella, Gokul Sarveswaran, Yuvaraj Krishnamoorthy, K. Sivaranjini, Kalaiselvy Arikrishnan, SGanesh Kumar   +5 more
semanticscholar   +1 more source