Results 81 to 90 of about 920 (198)

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe, Michael Apollinaro, Joanna Reeves, Christopher Nester, Leah R. Bent   +4 more
wiley   +1 more source

Applying the MIMO BP Neural Network and Cloud-Based Monitoring of Thermal Behavior for High-Speed Motorized Spindle Units

Machines
Understanding the temperature–working condition relationship is crucial for optimizing machining processes to ensure dimensional accuracy, surface finish quality, and overall spindle longevity.
Milos Knezev, Robert Cep, Luka Mejic, Branislav Popovic, Aco Antic, Branko Strbac, Aleksandar Zivkovic   +6 more
doaj   +1 more source

Cell Surface Markers Identify Astrocyte Subpopulations in the Adult Hippocampus With a Heterogeneous Response to Aging

Glia, Volume 74, Issue 11, November 2026.
ATP1B2 and GLAST identify two astrocyte subpopulations in the hippocampus with distinct molecular signatures. Transcriptomic shifts during aging differ between both subpopulations. Aged ATP1B2+ astrocytes rewire their metabolism while double‐positive aged astrocytes display a reduced synaptogenic capability.
Lucía Casares‐Crespo, Marife Cano‐Jaimez, Raquel Anta, Alba Ripollés‐Boix, Fabián Robledo‐Yagüe, Sheila Zúñiga‐Trejos, Helena Mira   +6 more
wiley   +1 more source

Simulation study on the influence of the structure of the cooling water jacket of the motorized spindle on thermal characteristics

Case Studies in Thermal Engineering
As a core component of high-end CNC machine tools, the thermal characteristics of motorized spindles directly affect the machining accuracy and operational stability of the machine tool.
Ruibin Liu, Fuzeng Wang, Dongju He, Feng Jiang   +3 more
doaj   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

SIMULATION AND EXPERIMENTAL STUDY ON THE STATIC STIFFNESS OF HIGH SPEED MOTORIZED SPINDLE

Jixie qiangdu, 2017
The static stiffness of the spindle is an important index to evaluate the static characteristics of the motorized spindle,which is essential to ensure the machining accuracy of precision CNC machine tools.Based on the calculation formulas of cutting ...
CUI FangYuan, LI Yan, YU JiaYi, TANG AoFei, LI PengYang, HAN LiLi   +5 more
doaj  

Whole‐Night Gentle Rocking Improves Sleep in Poor Sleepers With Insomnia Complaints

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Specific brain oscillations can be manipulated during sleep to improve sleep quality and memory performance. We previously demonstrated that continuous rocking stimulation (0.25 Hz, lateral movement) applied to good sleepers during sleep enhanced stable deep sleep, boosted NREM oscillations (spindles and slow waves) and memory consolidation ...
Aurore A. Perrault, Nathan E. Cross, Thien Thanh Dang Vu, Sophie Schwartz, Laurence Bayer   +4 more
wiley   +1 more source

Thermal–hydraulic optimization of a biomimetic leaf-vein cooling jacket for high-speed motorized spindles

Case Studies in Thermal Engineering
High-speed motorized spindles operating under high power density are susceptible to excessive temperature rise and non-uniform thermal deformation, which deteriorate machining accuracy, thermal stability, and service life. Achieving uniform and efficient
Ye Dai, Cheng Yang, Shiqiang Zhan, Gang Wang, He Hao, Yongjia Huang, Chuang Ming   +6 more
doaj   +1 more source

Differences in Sleep Spindle Characteristics Between Children With Narcolepsy and Those With Other Causes of Subjective Sleepiness

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Central disorders of hypersomnolence are characterised by excessive daytime sleepiness. There has been growing interest in analysing sleep micro‐architecture, to further understand how sleep is affected by these conditions. We investigated if sleep spindle activity differed between children with narcolepsy, idiopathic hypersomnolence (IH) and ...
Marisha Shetty, Nushrika Kadam Kishore, Georgina Plunkett, Lauren C. Nisbet, Margot J. Davey, Gillian M. Nixon, Lisa M. Walter, Rosemary S. C. Horne   +7 more
wiley   +1 more source