Results 181 to 190 of about 180,713 (315)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Reliability Assessment of High-Speed Train Gearbox Based on Digital Twin and WHO-WPHM. [PDF]

Sensors (Basel)
Wang T, Chen Y, Li S, Lv J, Liu Y, Yang J, Yan Q.   +6 more
europepmc   +1 more source

Geovisualizing cancelled air and high-speed train services during the outbreak of COVID-19 in China. [PDF]

J Transp Geogr, 2021
Wang J, Du D, Ma L.
europepmc   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Advanced Diagnostics of Position Sensors for the Actuation Systems of High-Speed Tilting Trains

, 2010
Trains tilting permits a train to travel at a high speed while maintaining an acceptable passenger ride quality with respect to the lateral acceleration, and the consequent lateral force, received by the passengers when the train travels on a curved ...
Tomassini, L., Risso, D., Sorli, Massimo, Jacazio, Giovanni   +3 more
core  

Advancing Circular Economy Implementation for High-Speed Train Rolling Stocks by the Integration of Digital Twins and Artificial Intelligence. [PDF]

Sensors (Basel)
Khongsomchit L, Kaewunruen S.
europepmc   +1 more source

Influence of Vehicle Number on the Dynamic Characteristics of High-Speed Train-CRTS III Slab Track-Subgrade Coupled System. [PDF]

Materials (Basel), 2021
Xu Q, Sun H, Wang L, Xu L, Chen W, Lou P.   +5 more
europepmc   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source

Fault detection of high-speed train wheelset bearings based on improved auxiliary classifier generative adversarial networks and VAE. [PDF]

PLoS One
Qiu J, Liu J, Tang M, Zhang D, Li M.
europepmc   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source