Results 251 to 260 of about 565,052 (292)

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

open access: yesAdvanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim   +10 more
wiley   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu   +10 more
wiley   +1 more source

High Tech @ Home

IEEE Computer Graphics and Applications, 2015
Although no one has yet to recreate Rosie from the animated sitcom The Jetsons, now more than half a century later there are some recently released and upcoming products that capture aspects of that highly skilled household robot. Recognizing family members; reminding them of tasks and events; following them through the house with music, movies, and ...
Lisa Avila, Mike Bailey
openaire   +2 more sources

High-Tech Facelift

Aesthetic Plastic Surgery, 1998
Recent technological advances in our specialty have made us reappraise the way we approach facial rejuvenation. Some of these technological interfaces have made it possible, in the author's experience, to improve results and to tackle difficult aesthetic problems.
openaire   +2 more sources

High tech cheating

Nurse Education in Practice, 2006
The use of technology has enhanced the convenience, flexibility, and efficiency of both preparatory and continuing education. Unfortunately, academic dishonesty, including plagiarism, has shown a positive correlation with the increased use of technology in education.
openaire   +5 more sources

High-TECh thymus

Blood, 2008
In this issue of Blood , Kelly and colleagues provide a possible solution to poor thymic function and prolonged immune deficiency following allogeneic BMT by demonstrating the additive benefit of combining KGF with androgen blockade to speed recovery of thymic function and reconstitution ...
openaire   +2 more sources

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