Results 161 to 170 of about 17,164,985 (308)

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

open access: yesAdvanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen   +7 more
wiley   +1 more source

BUILDING AN EFFECTIVE MOTIVATION SYSTEM AS A WAY TO MANAGE THE INNOVATION PROCESS AT ENTERPRISES OF HIGH-TECH INDUSTRIES

open access: yesМодели, системы, сети в экономике, технике, природе и обществе
Background. The article is devoted to one of the most urgent tasks in organizations of high-tech industries to build a motivation system that allows accelerating the pace of development of the Russian economy in the face of sanctions pressure, a shortage
S.S. Chebotarev, A.V. Romanova
doaj   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

open access: yesAdvanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen   +11 more
wiley   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

open access: yesAdvanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li   +7 more
wiley   +1 more source

Mechanically Robust, Self‐Healable, and Cryotolerant GelMA Hydrogel for Wearable Tactile Sensors with Enhanced Durability, Lifetime, and Environmental Stability

open access: yesAdvanced Science, EarlyView.
A mechanically robust, self‐healable, moisturizing, cryotolerant and adhesive GelMA hydrogel is developed by incorporating polyvinyl alcohol, acrylic acid, sodium tetraborate, and glycerol into GelMA matrix via a photoinitiated polymerization process. The hydrogel‐derived omni‐healable ionotronic pressure sensor can sensitively and consistently monitor
Zhikang Li   +16 more
wiley   +1 more source

Non‐Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice

open access: yesAdvanced Science, EarlyView.
Non‐invasively quantitative Raman imaging with stacking‐induced charge transfer‐enhanced Raman scattering (SICTERS) enables accurate measurement of concentrations and pharmacokinetic modeling of lymphatic transport of micelles in mice. This platform allows dynamic analysis of nanoparticle transport and underpins the design of effective lymph node ...
Yunlu Li   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy