Results 31 to 40 of about 5,508 (264)

Study of Short Times Tempering for AISI D2 Cold Work Tool Steel

open access: yesMaterials Research, 2023
Short time tempering has been applied to steels to improve toughness keeping the hardness at the same level. For AISI D2 tool steel, typical thermal cycles are quench and temper.
Maycoln D. Conci   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Tempering Temperature Influence on 13Cr4Ni0.02C Steel Corrosion Resistance [PDF]

open access: yesMaterials Research, 2017
The thermal treatments employed in alloys are essential to obtaining desired microstructures and corrosion resistance properties. In this paper the low carbon martensitic steel 13Cr4Ni0.2C with different tempering temperatures was studied using ...
Mérilin Cristina dos Santos Fernandes   +5 more
doaj   +1 more source

Microstructure and mechanical properties of a novel cast multi-phase stainless steel

open access: yesJournal of Materials Research and Technology, 2022
Cast stainless steels with high strength and toughness are very important for industrial production, but the strengthening methods are very limited.
Zixiang Wu   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Microstructural Investigation and Impact Strength of Sinter-Hardened PM Steels: Influence of Ni Content and Tempering Temperature

open access: yesMetals, 2023
This study analyzed the influence of tempering treatment temperature on the microstructural and mechanical behavior of two different powder metallurgy steels containing 0 wt. % Ni and 4 wt. % Ni.
Alessio Suman   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Effect of Heat Treatment on Mechanical Properties of 34CrNi3Mo Cast Steel

open access: yes工程科学与技术, 2012
: In order to research the effects of different heat treatment processes on mechanical properties of 34CrNi3Mo cast steel, the mechanical properties were compared in the condition of four kinds of heat treatment technologies which were “water ...
Wang De-fang, Yang Gang
doaj  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

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