Results 41 to 50 of about 17,220,096 (291)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
International Journal of Automotive Engineering, 2022 Ammonia is a kind of energy carrier of hydrogen, and its use as engine fuel has been studied. However, it requires overcoming shortcomings of low combustion speed. We focus that the laminar combustion velocity of gasoline mixture with an excess air ratio
Bin Guo +6 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
High-Ratio Nonlinear Compression of Picosecond Lasers Based on Thin Plates
PhotonicsNonlinear compression, as a newly developed post-processing technique, holds the potential to overcome the limitations of gain media and significantly reduce the pulse width of emitted laser pulses.
Kainan Zhou +8 more
doaj +1 more source
Effective compression and classification of ECG arrhythmia by singular value decomposition
Biomedical Engineering Advances, 2021 Electrocardiogram (ECG) monitoring systems are widely applied to tele-cardiology healthcare programs nowadays, where ECG signals should always be compressed first during its transmission and storage.
Lijuan Zheng +4 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
SensorsA common challenge in direct digital frequency synthesizers (DDFSs) is obtaining high memory compression while maintaining good output signal purity.
Kalle I. Palomäki, Jari Nurmi
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2022 Advances in computed tomography (CT) have resulted in a substantial increase in the size of datasets. We built a new concept of medical image compression that provides the best compromise between compression rate and image quality. The method is based on
Guillaume Fahrni +4 more
doaj +1 more source