Results 41 to 50 of about 443,378 (357)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

High cycle torsional fatigue properties of 17-4PH stainless steel [PDF]

Fracture and Structural Integrity, 2016
Sensitivity to small defects under torsional fatigue loading condition is examined in the high cycle fatigue regime. Fatigue crack initiation and small crack growth behaviors were observed during fatigue testing and fractographic investigations were ...
K. Yanase, B.M. Shönbauer, M. Endo
doaj   +2 more sources

Optimized processing method of P-S-N curves for high cycle fatigue of aero-engine materials

Journal of Aeronautical Materials, 2020
High cycle fatigue P-S-N curve of material are important for the design of aero-engine strength. Based on the data processing requirement of the high cycle fatigue of aero-engine materials, a novel data processing method has been developed by proposing ...
XU Wei, CHEN Xin, LI Xudong, ZHONG Bin, ZHAO Yanguang, TAO Chunhu   +5 more
doaj   +1 more source

Multiaxial high-cycle fatigue modelling for random loading [PDF]

MATEC Web of Conferences, 2019
In this paper, a multiaxial fatigue life prediction model is proposed under general multiaxial random loadings. First, a brief review for existing multiaxial fatigue models is given and special focus is on the LiuMahadevan critical plane concept, which ...
Wei Haoyang, Chen Jie, Carrion Patricio, Imanian Anahita, Shamsaei Nima, Iyyer Nagaraja, Liu Yongming   +6 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Effect of ultrasonic nanocrystal surface modification on the characteristics of AISI 310 stainless steel up to very high cycle fatigue [PDF]

, 2016
Effects of ultrasonic nanocrystal surface modification (UNSM) on the very high cycle fatigue response of AISI 310 stainless steel have been investigated. The higher impact force used in UNSM treatment showed a higher fatigue life improvement. The fatigue
Amanov, Amanov, Cao, Cherif, Dorman, Huang, Khan, Khan, Murakami, Pyoun, Sakai, Sakai, Shiozawa, Shiozawa, Suh, Suh, Suh, Trsko, Wang, Wu, Zhang, Zhou   +21 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Cumulative Damage in Very High/Low Cycle Combined Fatigue for TC21 Titanium Alloy

Crystals, 2022
The effect of low cycle fatigue (LCF) predamage with no precracks on very high cycle fatigue (VHCF) properties, and crack initiation characteristics for TC21 titanium alloy, was investigated.
Baohua Nie, Shuai Liu, Yue Wu, Yu Song, Haiying Qi, Binqing Shi, Zihua Zhao, Dongchu Chen   +7 more
doaj   +1 more source

Creep fatigue life assessment of a pipe intersection with dissimilar material joint by linear matching method [PDF]

, 2016
As the energy demand increases the power industry has to enhance both efficiency and environmental sustainability of power plants by increasing the operating temperature.
Barbera, Daniele, Chen, Hao Feng, Liu, Ying Hua   +2 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source