Results 161 to 170 of about 22,393,926 (290)
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
High Dynamic Range Images Using Exposure Metering
, 2007 在真實的世界裡，景色的亮度差異是非常大的。我們人眼可以同時觀察到很暗及很亮的影像，也就是人眼能適應較大的亮度差異；然而，現在的相機因為裝置結構上的限制，因此無法取得較大的動態範圍影像。所以我們的研究致力於如何取得高動態範圍的影像。 有學者提出利用不同曝光時間來重建出高動態範圍影像的方法。因此我們延伸他們的方法，提出了如何選擇曝光比較好的照片來建立高動態影像的照片。我們的方法主要是量測影像的曝光亮度，然後決定這張照片是否適合我們。使用我們的方法除了能減少時間來重建取得高動態範圍影像外 ...
Chen, Kun-Yi, 陳坤毅
core
Video reconstruction of variable VLBI observations with neural fields. [PDF]
NatureFoschi M +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
High-speed atomic force microscopy of membrane proteins: From dynamic imaging to integrative structural biology. [PDF]
Curr Opin Struct BiolShin E, Mount J, Scheuring S.
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Realization of long axial field-of-view PET technology in the clinic and research environment. [PDF]
Br J RadiolMuller FM +4 more
europepmc +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley +1 more source