Results 121 to 130 of about 1,129,002 (309)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
High-Energy-Density, Long-Life Li-Metal Batteries via Application of External Pressure
The application of commercially available carbonate-based electrolytes to Li-metal batteries (LMBs) is challenging because of the uncontrollable side reactions of the electrolytes with Li anodes.
Jae-Min Kim (112584) +4 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Energetic Materials FrontiersEnergetic materials are the energy materials used by weaponry to accomplish launch, propulsion, and destruction. However, during manufacture, storage and use, they may be damaged and form microcracks when subjected to external stimuli such as temperature,
Xing-ling Hu +5 more
doaj +1 more source
New Compound Xen14 with High Energy Density
Journal of Applied PhysicsAs a high-energy density material, polymeric nitrogen has attracted considerable attention, while the exceptionally high synthesis pressure hinders its studies and applications. A significant discovery indicates that the insertion of noble gas elements can effectively reduce the synthesis pressure of polymeric nitrogen compounds. This work utilized the
Chuanhao Shi +6 more
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Spatial Development and Energy Consumption [PDF]
Previous literature has suggested that the urban form (i.e., city size, density, and center distribution pattern) influences urban energy consumption.
Harrington, Winston +2 more
core
Enabling High-Energy-Density Cathode for Lithium–Sulfur Batteries
, 2018 High-energy lithium–sulfur (Li–S) battery is built on high loading and dense sulfur electrodes. Unfortunately, these electrodes usually suffer from a low sulfur utilization rate and limited cycle life due to the gap in scientific knowledge between the ...
Jie Xiao (113647) +8 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Energy Partition in Collisionless Counterstreaming Plasmas
The Astrophysical Journal LettersFast, counterstreaming plasma outflows drive magnetic field amplification, plasma heating, and particle acceleration in numerous astrophysical environments, from supernova remnant shocks to active galactic nuclei jets.
Alexis Marret, Frederico Fiuza
doaj +1 more source