Results 61 to 70 of about 1,388,734 (295)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Negative cosmological constant in the dark energy sector: tests from JWST photometric and spectroscopic observations of high-redshift galaxies [PDF]

Journal of Cosmology and Astroparticle Physics
Early observations with the James Webb Space Telescope (JWST) have revealed the existence of an unexpectedly large abundance of extremely massive galaxies at redshifts z ≳ 5: these are in tension with the predictions not only of the standard ΛCDM ...
N. Menci, Shahnawaz A. Adil, Upala Mukhopadhyay, A. A. Sen, S. Vagnozzi   +4 more
semanticscholar   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Fundamental Symmetries and Interactions - Some Aspects

, 2005
In the framework of nuclear physics and at nuclear physics facilities a large number of different experiments can be performed which render the possibility to investigate fundamental symmetries and interactions in nature.
Abele, Aguila, Babu, Bennett, Cho, Czarnecki, Dzuba, Endt, Escribano, Farley, Gorham, Hagiwara), Harris, Herczeg, Inami, Jungmann, Jungmann, K. Jungmann, Kawall, Klapdor-Kleingrothaus, Lee, Lobashov, Meijer, Nesvizhevsky, Pondrom, Regan, Romalis, Sakharov, Sandars, Scielzo, Semertzidis, Toner, Turkstra, Weinheimer   +33 more
core   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Effective Field Theory: A Modern Approach to Anomalous Couplings

, 2012
We advocate an effective field theory approach to anomalous couplings. The effective field theory approach is the natural way to extend the standard model such that the gauge symmetries are respected.
Aaltonen, Aaltonen, Aguilar-Saavedra, Aguilar-Saavedra, Aguilar-Saavedra, Alwall, Appelquist, Baur, Baur, Buchmuller, Campbell, Cen Zhang, Céline Degrande, De Rujula, Ellison, Falk, Gaemers, Gomis, Grojean, Grzadkowski, Grzadkowski, Hagiwara, Hagiwara, Hagiwara, Hagiwara, Harrison Mebane, Kilian, Leung, Longhitano, Longhitano, Nakamura, Nicolas Greiner, Olivier Mattelaer, Salam, Scott Willenbrock, Tim Stelzer, Weinberg, Weinberg, Weinberg, Weinberg, Willenbrock, Wolfgang Kilian, Wudka, Zeppenfeld   +43 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Role of the Theory of Planned Behavior in Explaining the Energy-Saving Behaviors of High School Students with Physical Impairments

Behavioral Sciences, 2022
People with physical impairments can help solve energy problems by participating in diverse energy-saving behaviors, such as switching off lights or turning off an air conditioner when not in use; however, they may struggle to participate in some behaviors due to mobility impairments.
Sirinakorn Suntornsan, Surapong Chudech, Piyapong Janmaimool   +2 more
openaire   +3 more sources