Results 191 to 200 of about 3,264,377 (259)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

High-frequency oscillations and sleep spindles in epilepsy: from mechanisms to modeling. [PDF]

Front Neurol
Zhao K, Wu M, Zhao J, Teng Y, Sun Z, Sun Y.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

High-frequency EEG synchronization modes as a stable biometric signature in humans. [PDF]

iScience
Vaezi H, Hossein-Zadeh GA.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Very high frequency ultrasonographic characteristics of poroma: a retrospective observational study. [PDF]

BMC Med Imaging
Dong B, Xia H, Xia Y, Chai L, Xie B, Liu Y.   +5 more
europepmc   +1 more source

Comparison of the Relationships Between Body Size and Cardiorespiratory Fitness With High Frequency Head-Motion Contamination in fMRI. [PDF]

Hum Brain Mapp
Pipoly M, Chappell H, DuBose LE, Madero B, Rivera-Dompenciel A, Sodoma M, Oehler C, Daniels W, Baller K, Springer J, Armstrong M, Nuckols V, Magnotta V, Long J, Pierce GL, Voss MW.   +15 more
europepmc   +1 more source

Ex Vivo High-Frequency Ultrasound of the Skin in the Morphologic Assessment of Basal Cell Carcinoma: A Comparative Study. [PDF]

Diagnostics (Basel)
Popa VT, Natarâș B, Tăban S, Ursoniu S, Dema A.   +4 more
europepmc   +1 more source

Temporal Dynamics and Clinical Relevance of Oscillatory Amplitude Variability During High-Frequency Oscillatory Ventilation With Volume Guarantee in Preterm Infants. [PDF]

Pediatr Pulmonol
Ali K, Alsenani M, Alshareedah S, Sufyani M, Algarni S, Alberti P, Homedi A, Alsaif S, Ali I, Dassios T, Greenough A.   +10 more
europepmc   +1 more source