Results 101 to 110 of about 16,886,684 (287)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Application of electro-optic modulation technique for PD monitoring of power transformers

Partial discharge (PD) detection is an important technique for assessing the health of high voltage power transformers. A partial discharge signal within an oil-filled power transformer may reach a winding first, then travel along the winding to the ...
Sutton, Simon, Tian, Y., Lewin, P.L., Swingler, S.G., Hao, L., Wilkinson, J.S.   +5 more
core   +1 more source

Feasibility of high-frequency alternating current power for motor auxiliary loads in vehicles

, 2011
This paper presents a feasibility study into the application of a 100-V, 50-kHz high-frequency ac (HFAC) network for powering automotive electrical auxiliaries. The study is focused on motor-actuated loads and is divided into two sections.
Nicholas D. Vaughan, James Marco, Marco, James, Antaloae, Ciprian C., Vaughan, Nicholas D., Ciprian C. Antaloae   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Power Electronic Transformer Using DC-DC Converter Based on Energy Injection Control

Kongzhi Yu Xinxi Jishu, 2017
In order to improve the power density and efficiency of power electronic transformer, this paper presented a power electronic transformer using DC-DC converter based on energy injection control.
ZHAO Ziyi, SU Mei, ZHU Qi, WANG Hui
doaj  

A high voltage gain solid-state transformer for integration of renewable energy and AC sources

Scientific Reports
This paper introduces a novel high-voltage gain topology for a solid-state transformer, integrating a DC-DC converter and dual active bridge converters. The proposed design features three DC links operating at different voltage levels.
Seyed Majid Hashemzadeh, Mohammed A. Al-Hitmi, Shirazul Islam, Atif Iqbal, Hadi Aghaei, Seyed Hossein Hosseini, Ebrahim Babaei   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Frequency-aware vision transformers for high-fidelity super-resolution of Earth system models

Scientific Reports
Super-resolution can play an essential role in enhancing the spatial fidelity of Earth System Model outputs, allowing fine-scale structures highly beneficial to climate science to be recovered from coarse simulations.
Ehsan Zeraatkar, Salah A. Faroughi, Jelena Tešić   +2 more
doaj   +1 more source