Results 171 to 180 of about 152,057 (309)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
High-frequency energy fusion (HFEF) for nuclei segmentation with boundary-aware loss. [PDF]
Quant Imaging Med SurgYin W, He W, Shang B, Zhao B, Wu X.
europepmc +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
3D Urban Outdoor WiFi 7 Network Planning and Analysis Using Ray-Tracing and Machine Learning: Transformer-Based Surrogate Modeling for High-Resolution Digital Twin. [PDF]
Sensors (Basel)Trînc EC +5 more
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
MM FD ConvFormer multimodal frequency aware deformable CNN transformer network for robust brain tumor classification. [PDF]
Sci RepArockia Selvarathinam ALXR +6 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Anomaly detection of cybersecurity behavior using cross-sequence aligned transformer-A dynamic recognition approach for high-frequency interaction patterns. [PDF]
PLoS OneHan S, Bin D, Ling Y, Lin C.
europepmc +1 more source
Manufacturability improvements of high frequency transformers
, 2014 M.Ing. (Electrical and Electronic Engineering) In order to improve the industrialisation of modern power converters, its physical size must be reduced, material must be utilised more efficiently and its manufacturability improved. Consequently, many converters are operated in the ultrasonic frequency range, where the size of its constituent components ...
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source