Results 41 to 50 of about 33,172 (312)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
High frequency link Uninterruptible Power Supply (UPS) system [PDF]
, 2013 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.The main aim of this thesis is to propose, design, simulate and build a new UPS system which can be used for compact applications.
Rasool, Emad Abdulrazzaq
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
High frequency inverter-transformer-cycloconverter system for DC to AC (3-phase) power conversion [PDF]
, 1991 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis is concerned with a 3-phase multistage high frequency link DC to AC power conversion with a novel inverter-cycloconverter circuitry.
Karamat, Asghar
core
Application of electro-optic modulation technique for PD monitoring of power transformers [PDF]
Partial discharge (PD) detection is an important technique for assessing the health of high voltage power transformers. A partial discharge signal within an oil-filled power transformer may reach a winding first, then travel along the winding to the ...
Sutton, Simon +5 more
core +1 more source
Transformers in High-Frequency Trading
Journal of Physics: Conference SeriesAbstract Transformer is a deep learning model that, having an innovative performance in many tasks, has uniquely and significantly modified all the cast of mind of the AI scientific community. In this paper, we introduce a Transformer model that is applied to 1-minute timescale in the EURUSD and GBPUSD instruments of forex trading.
Konstantinos T. Kantoutsis +2 more
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
EnergiesPartial discharge, as an important indicator of insulation degradation in transformers, is a crucial means of assessing the insulation performance of transformers.
Zhiqin Ma +6 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source