Results 51 to 60 of about 18,206,027 (285)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
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Vietnam Journal of Education, 2022 In the context of English as a foreign language (EFL) teaching, textbooks play a crucial role in the classroom as the primary source of lexical input for learners.
Nguyet Thi Minh Le, Huong Thi Dinh
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Frontiers in PsychologyIntroductionHomonyms are words with multiple, unrelated meanings that share a single form and pronunciation. These words provide valuable insights into how semantic representation is retrieved and selected independently of orthography and phonology. This
Joonwoo Kim, Sangyub Kim, Kichun Nam
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Dissociation of sensitivity to spatial frequency in word and face preferential areas of the fusiform gyrus [PDF]
, 2011 Different cortical regions within the ventral occipitotemporal junction have been reported to show preferential responses to particular objects.
Woodhead, Z +14 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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What are the collocational exemplars of high-frequency English vocabulary? on identifying Mwus most representative of high-frequency, lemmatized concgrams [PDF]
, 2016 Collocations, simply defined, are words that have a high frequency of co-occurrence (Biber et al., 1999: Shin, 2006). Collocational fluency is an essential aspect of communicating in and comprehending a second language in a native-like fashion.
Rogers, James M.
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FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
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