Results 131 to 140 of about 145,315 (349)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

High Gain Ripple Less DC-DC Power Converter for EV Application

, 2022
Dr. S. Parthasarathy, R. Thangasankaran, P. Clement Paul, M. Arjun   +3 more
openalex   +1 more source

Modified High Gain DC-DC Converter with APICs for Microgrid [PDF]

, 2022
G. Amritha, G. Kanimozhi, K. Mohana Sundaram, L. Natrayan, Kiran Ramaswamy   +4 more
openalex   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

An analytical design and analysis of a high gain switched inductor voltage multiplier cell power converter

Automatika
The proposed modified higher gain boost converter employs switched Inductor and multiplier cell-based voltage boosting techniques, as the paper represents. This converter is modelled to enhance the static gain and efficiency. As the designed topology has
K. Jayanthi, J. Gnanavadivel
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adaptive neuro-fuzzy approach for maximum power point tracking with high gain converter for photo voltaic applications [PDF]

, 2022
S Narthana, P. Thiruvengadam, J. Gnanavadivel, L Jiang, R Srivatsan, D Maskell, Al-Majidi Sd, M Abbod, Al-Raweshidy Hs, U Yilmaz, O Turksoy, A Teke, L Farah, A Haddouche, A Haddouche, R Moyo, P Tabakov, S Moyo, Al-Majidi Sd, M Abbod, Al-Raweshidy Hs, M Lakshmi, S Hemamalini, N Tewari, V Sreedevi, T Arunkumari, V Indragandhi, G Arunkumar, P Sanjeevikumar, Holm-Nielsen, Jb, S Ansari, J Moghani, Y Zeng, H Li, W Wang, B Zhang, T Zheng, Abdel-Rahim O Wang, H, R Asif, R Ur, R Ur, J Arshad, J Hamid, S Tariq, D Bao, A Kumar, X Pan, X Xiong, A Beig, S Singh, M Kalarathi, K Jayanthi, M Abbasi, Y Nazari, E Abbasi, L Li, A Mizani, S Ansari, A Shoulaie, J Davidson, M Foster, S Khan, M Zaid, A Mahmood, A Nooruddin, J Ahmad, M Alghaythi, C Basha, M Murali, A Rajabi, A Rajaei, V Tehrani, P Dehghanian, J Guerrero, B Khan, S Saravanan, R Usha, M Thakre, S Pirpoor, S Rahimpour, M Andi, N Kanagaraj, S Pirouzi, A Mohammed, B Faridpak, M Bayat, M Nasiri, R Samanbakhsh, M Farrokhifar, Al-Hitmi M Maroti, P Iqbal, A, A Andrade, T Faistel, R Guisso, A Toebe, S Hasanpour, Y Siwakoti   +99 more
openalex   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

High-Voltage Gain Single-Switch Quadratic Semi-SEPIC Converters for Powering High-Voltage Sensors Suitable for Renewable Energy Systems and Industrial Automation with Low Voltage Stresses

Sensors
This paper presents two new non-isolated DC-DC converters with and without a coupled inductor based on quadratic voltage conversion. Firstly, the coupled inductor-less type is explained in detail.
Frederick Nana Oppong, Soroush Esmaeili, Ashraf Ali Khan   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source