Results 51 to 60 of about 16,300,519 (236)
The Influence of Non-Uniform High Heat Flux on Thermal Stress of Thermoelectric Power Generator
Energies, 2015 A thermoelectric generator (TEG) device which uses solar energy as heat source would achieve higher efficiency if there is a higher temperature difference between the hot-cold ends.
Tingzhen Ming +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Jin'gangshi yu moliao moju gongchengWith the rise of third-generation semiconductors, electronic devices are evolving towards high-power, miniaturization, and integration. Traditional heat dissipation technologies are no longer sufficient to meet the heat dissipation requirements of high ...
Shibo DENG +4 more
doaj +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Optimization of stepwise varying width microchannel heat sink for high heat flux applications
Case Studies in Thermal Engineering, 2020 The semiconductor devices are widely employed for many applications. A significant amount of the heat must be dissipated properly to keep the devices' performance stable.
Essam M. Abo-Zahhad +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Measurement and parameterisation of the air-sea CO2 flux in high winds
, 2011 During a three year occupation of Station Mike (66°N 2°E), the Norwegian Ocean Weather Ship Polarfront was equipped with a range of meteorological and seastate measuring instruments, including the autonomous air-sea flux system “AutoFlux” (Yelland et al.,
Prytherch, John
core +1 more source
Micromachines, 2016 Digital microfluidics (DMF) driven by electrowetting-on-dielectric (EWOD) has recently been attracting great attention as an effective liquid-handling platform for on-chip cooling.
Sung-Yong Park, Youngsuk Nam
doaj +1 more source