Results 111 to 120 of about 17,685,281 (294)

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik   +3 more
wiley   +1 more source

Post‐Task Management of Biomedical Microrobots Toward Clinical Translation: Biodegradable and Retrievable Strategies

open access: yesSmartBot, EarlyView.
Microrobots offer new opportunities for minimally invasive biomedical applications, including targeted therapy, in vivo sensing, and disease diagnosis. This review highlights biodegradable and retrievable strategies for post‐task management, focusing on material degradation, active retrieval, and the integration of both approaches to improve biosafety ...
Yiqi Yin, Miao Ma, Zhongyi Li, Jing Zhao
wiley   +1 more source

Oral non‐steroidal anti‐inflammatory drugs do not delay corneal healing in dogs with spontaneous chronic corneal epithelial defects: A retrospective cohort of 186 ulcers

open access: yesVeterinary Record, EarlyView.
Abstract Background Oral non‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly used for analgesia in dogs with spontaneous chronic corneal epithelial defects (SCCEDs). Topical NSAIDs can delay epithelialisation and promote stromal melting, but the safety of systemic NSAIDs in SCCEDs is unknown.
Kaitlyn Scheunemann   +2 more
wiley   +1 more source

Anti‐obesity medications and incident ocular outcomes: A systematic review and network meta‐analysis

open access: yesVIEW, EarlyView.
In this systematic review and network meta‑analysis of 140 studies, anti‑obesity medications showed heterogeneous ocular safety profiles. Semaglutide was associated with higher NAION risk (observational data), whereas dual/multi‑agonists and glucagon‐like peptide‐1 receptor agonists demonstrated favourable glaucoma and overall ocular outcomes ...
Linge Jian   +5 more
wiley   +1 more source

Phacoemulsification combined with goniosynechialysis for acute angle-closure glaucoma: impact of preoperative IOP status

open access: yesBMC Ophthalmology
Précis Treatment of acute angle-closure glaucoma with phacoemulsification combined with goniosynechialysis significantly improves patients’ visual acuity and reduce intraocular pressure; the preoperative condition has minimal influence on the treatment ...
Chan Xiong   +8 more
doaj   +1 more source

Measurement of intraocular pressure during laparoscopy and its relationship to central venous pressure.

open access: yes, 1998
UNLABELLED STUDY OBJECTIVE. To determine the effect of different positional degrees on hemodynamics, especially central venous pressure and intraocular pressure, and a possible interrelationship, during laparoscopic surgery. SETTING.
Dekker PW   +4 more
core   +1 more source

Retinal neurovascular alterations are associated with optic radiation microstructure in adrenomyeloneuropathy: A susceptibility separation MRI study

open access: yesVIEW, EarlyView.
In a cross‐sectional cohort of 104 participants, 7 T susceptibility separation MRI and diffusion imaging were combined with retinal imaging and visual evoked potentials to characterize visual pathway involvement in adrenomyeloneuropathy (AMN). Absolute diamagnetic susceptibility, a myelin‐associated measure, and fractional anisotropy (FA) showed ...
Ronghao Li   +17 more
wiley   +1 more source

Absolute and relative reductions in intraocular pressure.

open access: yes, 2013
Absolute and relative reductions in intraocular pressure.
Rui-Li Wei (305046)   +4 more
core   +1 more source

Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
David W. Kennedy   +2 more
wiley   +1 more source

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