Results 121 to 130 of about 3,465,717 (304)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Design of miniaturized high isolation UWB-MIMO antenna

Zhongguo Jianchuan Yanjiu
ObjectiveAiming at problems with shipboard wireless communication equipment such as its compact layout, limited space, and serious electromagnetic interference between devices, a miniaturized ultra-wideband multiple-input multiple-output (UWB-MIMO ...
Qi ZHANG, Li'an BIAN, Shu XIE, Yan WANG, Renbin LIU   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Active Quasi-Circulator Based on Wilkinson Power Divider for Low-Power Wireless Communication Systems

Journal of Low Power Electronics and Applications
This paper presents a microstrip active quasi-circulator designed for low-power wireless communication systems. The circuit consists of a second-order Wilkinson power divider and two power amplifiers with high gain and ultra-low noise characteristics. By
Kaijun Song, Xinsheng Chen, Zongrui He
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Design and Investigation of Orthogonal Hybrid Dual-Mode Single-CDR-Based MIMO Antenna With High Self-Isolation at 5.8GHz

IEEE Access
In this article, a dual-port single-element coaxial probe-fed cylindrical dielectric resonator MIMO antenna is designed and investigated. The high-permittivity dielectric ( ${\varepsilon }_{\mathrm {r}}=15$ ) is composed of barium-titanate-doped ...
Samira Mekki, Atul Varshney, Djamel Sayad, Issa Elfergani, Hanane Bendjedi, Mohamed Lamine Bouknia, Rami Zegadi, Jonathan Rodriguez, Merih Palandoken, Kamil Karacuha, Chemseddine Zebiri   +10 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A Dual-Polarized Stacked Ceramic Antenna With High Isolation

IEEE Access
In this work, two identical ceramic plates formed a stacked dense dielectric patch antenna is introduced for implementing a dual-polarized antenna. The proposed stacked ceramic structure generates highly pure adjacent modes, achieving wide impedance ...
Liyuan Cao, Wenjian Sun, Hang Wong
doaj   +1 more source

High Isolation, Double-Clamped, Magnetoelectric Microelectromechanical Resonator Magnetometer. [PDF]

Sensors (Basel), 2023
Mion T, D'Agati MJ, Sofronici S, Bussmann K, Staruch M, Kost JL, Co K, Olsson RH, Finkel P.   +8 more
europepmc   +1 more source