Results 251 to 260 of about 37,800,474 (344)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Urea-functionalized HKUST-1 metal-organic framework for high-performance lead adsorption. [PDF]

RSC Adv
Hashad NM, Nassar MY, Jahin HS, El-Nahas AM, Adam MSS, Kamoun EA, Alfurayj I, Ayoup MS, El-Demerdash SH, Abou-Elyazed AS.   +9 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Factors influencing the high performance of IT staff. [PDF]

Sci Rep
Moura I, Varajão J.
europepmc   +1 more source

High performance GPU implementation of KNN algorithm: A review. [PDF]

MethodsX
Bidye P, Borkar P, Rakesh N.
europepmc   +1 more source

Design of high-performance sustainable aluminum alloy series for laser additive manufacturing. [PDF]

Nat Commun
Takata N, Minamihama K, Miyawaki T, Cheng Y, Xu Y, Wang W, Kim D, Suzuki A, Kobashi M, Kato M.   +9 more
europepmc   +1 more source

Algorithm-Guided Experimentation for Optimization of High-Performance Perovskite Solar Cells. [PDF]

ACS Energy Lett
Oh D, Kim S, Perini CAR, Correa-Baena JP, Sahinidis NV.   +4 more
europepmc   +1 more source

High Performance Polymeric Fabry-Pérot Microcavities for Sensing and Lasing Applications. [PDF]

Polymers (Basel)
Testa G, Coviello V, Persichetti G, Bernini R.   +3 more
europepmc   +1 more source

Ultralong Hydroxyapatite Nanowires: Promising Flexible Building Blocks for Constructing High-Performance Biomimetic Materials-A Review. [PDF]

Molecules
Yu HP, Zhu YJ.
europepmc   +1 more source

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HIGH-PERFORMANCE COMPUTING MEETS HIGH-PERFORMANCE MEDICINE

Biocomputing 2023, 2022
The following sections are included: Introduction, Background, and Motivation, Workshop Presenters, References.
Anurag, Verma, Jennifer, Huffman, Ali, Torkamani, Ravi, Madduri   +3 more
openaire   +2 more sources