Results 241 to 250 of about 22,385,248 (304)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Discovery of novel acetylcholinesterase inhibitors through AI-powered structure prediction and high-performance computing-enhanced virtual screening. [PDF]

RSC Adv
Chafer-Dolz B, Cecilia JM, Imbernón B, Núñez-Delicado E, Casaña-Giner V, Cerón-Carrasco JP.   +5 more
europepmc   +1 more source

RETRACTED ARTICLE: COVID-19 Detection using adopted convolutional neural networks and high-performance computing.

Multimed Tools Appl
Singh AK, Kumar A, Kumar V, Prakash S.
europepmc   +1 more source

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High-Performance Computing with TeraStat

2020 IEEE Intl Conf on Dependable, Autonomic and Secure Computing, Intl Conf on Pervasive Intelligence and Computing, Intl Conf on Cloud and Big Data Computing, Intl Conf on Cyber Science and Technology Congress (DASC/PiCom/CBDCom/CyberSciTech), 2020
In the last years we are witnessing a progressive shift toward the adoption of the cloud-computing model for a large variety of application domains. High-performance computing (HPC) is not an exception to this trend, with a steadily increasing amount of performance-heavy scientific experiments that are conducted on the cloud. However, this approach may
Edoardo, Bompiani, Jona-Lasinio, Giovanna, Ferraro-Petrillo, Umberto, Francesco, Palini   +3 more
openaire   +3 more sources

Introduction to High-Performance Computing

2023
Since the first general-purpose computing machines came up in the middle of the twentieth century, computer science's popularity has been growing steadily until our time. The first computers represented a significant leap forward in automating calculations, so that several theoretical methods could be taken from paper into practice. The continuous need
Marco, Verdicchio, Carlos, Teijeiro Barjas   +1 more
openaire   +2 more sources

High-Performance Computing with Accelerators

Computing in Science & Engineering, 2010
This issue of CiSE is based on work presented at the US National Science Foundation workshop, Path to Petascale: Adapting Geo/Chem/Astro Applications for Accelerators and Accelerator Clusters, held at the US National Center for Supercomputing Applications (NCSA) in early 2009.
Volodymyr V. Kindratenko, Robert B. Wilhelmson, Robert J. Brunner, Todd J. Martínez, Wen-mei W. Hwu   +4 more
openaire   +1 more source