Results 141 to 150 of about 20,680,470 (306)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Anion Storage Chemistry of Organic Cathodes for High-Energy and High-Power Density Divalent Metal Batteries. [PDF]

Angew Chem Int Ed Engl, 2023
Xiu Y, Mauri A, Dinda S, Pramudya Y, Ding Z, Diemant T, Sarkar A, Wang L, Li Z, Wenzel W, Fichtner M, Zhao-Karger Z.   +11 more
europepmc   +1 more source

2017 CPES Annual Report

, 2017
In its effort to develop power processing systems to take electricity to the next step, CPES has cultivated research expertise encompassing five technology areas: (1) power conversion technologies and architectures; (2) power electronics components; (3 ...
Center for Power Electronics Systems, Uncork-it, Inc.   +1 more
core  

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

A New Integrated GDL with Wavy Channel and Tunneled Rib for High Power Density PEMFC at Low Back Pressure and Wide Humidity. [PDF]

Adv Sci (Weinh), 2023
He C, Wen Q, Ning F, Shen M, He L, Li Y, Tian B, Pan S, Dan X, Li W, Xu P, Liu Y, Chai Z, Zhang Y, Liu W, Zhou X.   +15 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

High-temperature low-humidity proton exchange membrane with "stream-reservoir" ionic channels for high-power-density fuel cells. [PDF]

Sci Adv, 2023
Guan P, Zou Y, Zhang M, Zhong W, Xu J, Lei J, Ding H, Ding H, Feng W, Liu F, Zhang Y.   +10 more
europepmc   +1 more source

Stability enhanced polyelectrolyte-coated gold nanorod-photosensitizer complexes for high/low power density photodynamic therapy

, 2014
Photodynamic therapy (PDT) is a promising treatment modality for cancer and other malignant diseases, however safety and efficacy improvements are required before it reaches its full potential and wider clinical use.
Chen, Xiaoyuan, Shi, Zhenzhi, Zhao, Xinmei, Wu, Aiguo, Ren, Wenzhi, Zou, Yuehong, Gong, An, Brown, Eric Michael Bratsolias   +7 more
core  

A Generalized Center-Aligned High-Resolution Pulse Width Modulator Implementation Using an Output Serializer in Field Programmable Gate Arrays

A digital pulse width modulator (DPWM) is a key component in digital power electronics. Techniques like space vector modulation, along with rising switching frequencies from wide-bandgap power transistors, create a need for a center-aligned high ...
Yixiao Wu, Zhong Wu
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source