Results 51 to 60 of about 745,483 (264)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

A Novel Segment-switching Strategy with the Current Transient Overshoot Suppression for Segmented Long-Stator Linear Motor

CES Transactions on Electrical Machines and Systems
The segmented power supply scheme for long-stator linear motor facilitates reducing power capacity and achieving a high power factor. However, the segment-switching process leads to overcurrent under high-speed conditions.
Yanfei Li, Zixin Li, Hang Zhang, Fei Xu, Cong Zhao, Fanqiang Gao, Yaohua Li   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Review of Optimization Methods for Pole-Shoe Structures in Large-Scale Salient Pole Synchronous Motors

CES Transactions on Electrical Machines and Systems
Optimizing the rotor pole-shoe structure of large salient pole synchronous motors is critical for improving their performance and efficiency, allowing for enhanced responsiveness to grid demands and adjustments in operating conditions.
Pengcheng Ma, Jinxiu Chen, Yiwei Ding
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Influence of Polytetrafluoroethylene Content, Compaction Pressure, and Annealing Treatment on the Magnetic Properties of Iron-Based Soft Magnetic Composites

Molecules
To improve the magnetic properties of iron-based soft magnetic composites (SMCs), polytetrafluoroethylene (PTFE) with excellent heat resistance, electrical insulation, and extremely high electrical resistivity was chosen as an insulating coating material
Mei Song, Fan Luo, Yajing Shang, Zhongxia Duan   +3 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

A Review of Research Methods for Stator Temperature Monitoring in PMSM

CES Transactions on Electrical Machines and Systems
High-density permanent magnet synchronous motors (PMSMs) are widely used in electric drive systems. However, they are susceptible to temperature influences under complex operating conditions, and prolonged operation at high temperatures can first damage ...
Songze Zhao, Puqi Ning, Tao Fan, Xiaoshuang Hui, Qibiao Shi   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Linear quadratic regulator-based coordinated optimization for harmonic compensation in multifunctional grid-connected inverters

International Journal of Electrical Power & Energy Systems
The increasing penetration of distributed energy resources (DERs) and electric vehicles (EVs) introduces widespread power electronic devices that significantly challenge harmonic mitigation in distribution systems.
Xianghua Peng, Jingyuan Yin, Jiancheng Yu, Jinzhao Song, Keyan Liu, Zhao Li, Tongzhen Wei   +6 more
doaj   +1 more source