Results 61 to 70 of about 744,243 (264)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Thrust Ripple Analysis and Precise Modeling of 12/13 Slot-Pole Linear Flux-Switching Permanent Magnet Motors

CES Transactions on Electrical Machines and Systems
Linear flux-switching permanent magnet motors (LFSPMs) have been proposed for long stator applications such as rail transit. However, the conventional linear permanent magnet synchronous motor (LPMSM) suffers from thrust ripple, which degrades the motor ...
Qi Wang, Ke Wang, Dihui Zeng, Lu Zhao, Wei Xu, Yaohua Li   +5 more
doaj   +1 more source

A High-Efficiency and High-Power-Density Partial Power Buck-Boost Converter

IEEE Journal of Emerging and Selected Topics in Power Electronics
This paper initiates a comprehensive exploration of two distinct partial power structures firstly, input-parallel output-series (IPOS) and input-series output-parallel (ISOP), emphasizing their specialized applications. Using efficiency and power processing models, the analysis determines the most suitable partial power topology based on specific ...
Di Wu, Pinhe Wang, Yanda Lyu, Michael A. E. Andersen, Ziwei Ouyang   +4 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Coordinated Capacitor Voltage Balancing Method for Cascaded H-Bridge Inverter with Supercapacitor and DC-DC Stage

CES Transactions on Electrical Machines and Systems
Cascaded H-bridge inverter (CHBI) with supercapacitors (SCs) and dc-dc stage shows significant promise for medium to high voltage energy storage applications.
Ye Zhang, Zixin Li, Fanqiang Gao, Cong Zhao, Yaohua Li   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Research progress in anode prelithiation techniques for lithium-ion energy storage devices

Cailiao gongcheng
Driven by the “dual-carbon” strategy，which accelerates energy structure transformation，the market demand for high-performance electrochemical energy storage systems has surged significantly.
WANG Hao, AN Yabin, LIU Yang, ZHANG Xiong, XU Jianwei, SUN Xianzhong   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Research Advances in the Design and Control Technologies of Electric Spindle Motors for CNC Machine Tools

Energies
The electric spindle serves as a critical component in enabling a highly dynamic response, stable torque output, and precise motion control for the main cutting operations of CNC machine tools.
Jinhua Liang, Haiping Xu, Fei Chen, Wei Liu, Peng Zhou   +4 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source