Results 101 to 110 of about 744,243 (264)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

High Power Density IGBT Loss Calculation Model and Analysis

Energies
This paper presents the establishment of an accurate loss model for high-power-density IGBT modules used in electric vehicles, leveraging the thermal simulation capabilities of the power electronics simulation software PLECS 4.1.
Feng Wang, Yifan Song, Wang Dou, Zhaolei Zheng, Zhuangzhuang Li, Biao Li, Jun Liu   +6 more
doaj   +1 more source

Half-Heusler alloys as emerging high power density thermoelectric cooling materials. [PDF]

Nat Commun, 2023
Zhu H, Li W, Nozariasbmarz A, Liu N, Zhang Y, Priya S, Poudel B.   +6 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Silicon-nitride-based entrance slit design for the high-power-density monochromator in TPS 45A. [PDF]

J Synchrotron Radiat, 2023
Hsu MY, Fu HW, Fung HS, Hua CY, Huang LJ, Tsai HM.   +5 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

High-Power-Density Thermoelectrochemical Cell Based on Ni/NiO Nanostructured Microsphere Electrodes with Alkaline Electrolyte. [PDF]

Nanomaterials (Basel), 2023
Artyukhov D, Kiselev N, Boychenko E, Asmolova A, Zheleznov D, Artyukhov I, Burmistrov I, Gorshkov N.   +7 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Innovative Bidirectional Isolated High-Power Density On-Board Charge for Vehicle-to-Grid. [PDF]

Sensors (Basel), 2022
Hrbac R, Hrdina L, Kolar V, Slanina Z, Blazek V, Vantuch T, Bartłomiejczyk M, Misak S.   +7 more
europepmc   +1 more source