Results 51 to 60 of about 744,243 (264)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

A Novel Segment-switching Strategy with the Current Transient Overshoot Suppression for Segmented Long-Stator Linear Motor

open access: yesCES Transactions on Electrical Machines and Systems
The segmented power supply scheme for long-stator linear motor facilitates reducing power capacity and achieving a high power factor. However, the segment-switching process leads to overcurrent under high-speed conditions.
Yanfei Li   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

A Review of Optimization Methods for Pole-Shoe Structures in Large-Scale Salient Pole Synchronous Motors

open access: yesCES Transactions on Electrical Machines and Systems
Optimizing the rotor pole-shoe structure of large salient pole synchronous motors is critical for improving their performance and efficiency, allowing for enhanced responsiveness to grid demands and adjustments in operating conditions.
Pengcheng Ma, Jinxiu Chen, Yiwei Ding
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Influence of Polytetrafluoroethylene Content, Compaction Pressure, and Annealing Treatment on the Magnetic Properties of Iron-Based Soft Magnetic Composites

open access: yesMolecules
To improve the magnetic properties of iron-based soft magnetic composites (SMCs), polytetrafluoroethylene (PTFE) with excellent heat resistance, electrical insulation, and extremely high electrical resistivity was chosen as an insulating coating material
Mei Song   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

A Review of Research Methods for Stator Temperature Monitoring in PMSM

open access: yesCES Transactions on Electrical Machines and Systems
High-density permanent magnet synchronous motors (PMSMs) are widely used in electric drive systems. However, they are susceptible to temperature influences under complex operating conditions, and prolonged operation at high temperatures can first damage ...
Songze Zhao   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Linear quadratic regulator-based coordinated optimization for harmonic compensation in multifunctional grid-connected inverters

open access: yesInternational Journal of Electrical Power & Energy Systems
The increasing penetration of distributed energy resources (DERs) and electric vehicles (EVs) introduces widespread power electronic devices that significantly challenge harmonic mitigation in distribution systems.
Xianghua Peng   +6 more
doaj   +1 more source

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