Results 81 to 90 of about 827,872 (311)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Research Advances in the Design and Control Technologies of Electric Spindle Motors for CNC Machine Tools

Energies
The electric spindle serves as a critical component in enabling a highly dynamic response, stable torque output, and precise motion control for the main cutting operations of CNC machine tools.
Jinhua Liang, Haiping Xu, Fei Chen, Wei Liu, Peng Zhou   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Enhanced Repetitive Control with Phase Compensation Based ADRC for Harmonic Suppression in Magnetically Suspended Rotor Under Strong Gyroscopic Effects

CES Transactions on Electrical Machines and Systems
Magnetically suspended rotor (MSR) systems have gained widespread industrial adoption owing to their frictionless operation and exceptional reliability.
Yuxiang Zhu, Fanqiang Gao, Kaiyu Shan, Zixin Li, Yaohua Li   +4 more
doaj   +1 more source

The novel LiMn1.8Al0.2O4 nanosheets for high energy and power density supercapacitor cathode applications

, 2023
A novel, oleic acid-assisted solution combustion synthesis route has been successfully explored to synthesize high surface area and mesoporous Al-doped LiMn2O4 nanosheets without the use of MnO2 templates.
R. A. Khan; S. A. Akhoon; G. V. Vijayaraghavan; S. Rubab; M. A. Shah; K. T. Arul; C. L. Dong
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Research on active damping voltage control considering leakage inductance of FOVRT transformer

International Journal of Electrical Power & Energy Systems
The Flexible on-load voltage regulating transformer (FOVRT) is realized through the integration of a small power converter with the conventional on-load voltage regulator transformer.
Longfei Sun, Jingyuan Yin, Ke-yan Liu, Dongli Jia, Zhao Li, Yu Jiancheng, Song Jinzhao, Tongzhen Wei   +7 more
doaj   +1 more source

A Dumbbell Shaped Piezoelectric Motor Driven by the First-Order Torsional and the First-Order Flexural Vibrations

, 2020
A piezoelectric motor driven by the first-order torsional and first-order flexural (T/F) vibrations is designed, fabricated, and tested in this study. The actuating force is generated by the torsional vibration of the dumbbell-shaped vibrator, while the ...
Jianye Niu, Li Chen, Qiming Liu, Jiang Wu, Shijie Guo   +4 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A static current error elimination algorithm for predictive current control in PMSM for electric vehicles

Green Energy and Intelligent Transportation
Permanent magnet synchronous motors (PMSM), especially interior PMSM, offer several benefits, including a compact design, light weight, simple construction, high efficiency, and versatile control capabilities, which make them ideal for use in electric ...
Lin Shen, Jian Zhang, Kai Chen, Xuhui Wen   +3 more
doaj   +1 more source