Results 51 to 60 of about 2,860,718 (307)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Two-loop HTL pressure at finite temperature and chemical potential

, 2013
We calculate the two-loop pressure of a plasma of quarks and gluons at finite temperature and chemical potential using the hard thermal loop perturbation theory (HTLpt) reorganization of finite temperature/density quantum chromodynamics.
Haque, Najmul, Mustafa, Munshi G., Strickland, Michael   +2 more
core   +1 more source

Crystal-Chemical Properties of Synthetic Almandine-Pyrope Solid Solution by X-Ray Single-Crystal Diffraction and Raman Spectroscopy

Crystals, 2019
Crystal-chemical properties of synthetic Almandine-Pyrope (Alm-Pyr) solid solutions were investigated by X-ray single-crystal diffraction and Raman spectroscopy.
Yunqian Kuang, Jingui Xu, Bo Li, Zhilin Ye, Shijie Huang, Wei Chen, Dongzhou Zhang, Wenge Zhou, Maining Ma   +8 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Fluidic packaging of microengine and microrocket devices for high pressure and high temperature operation

, 2004
The fluidic packaging of Power MEMS devices such as the MIT microengine and microrocket requires the fabrication of hermetic seals capable of withstanding temperature in the range 20-600/spl deg/C and pressures in the range 100-300 atm.
Harrison, T.S., Mracek, A., Peles, Y., Spearing, S.M., Srikar, V.T.   +4 more
core   +1 more source

Effect of Polarization on the O2(g), Au/YSZ Electrode System

International Journal of Electrochemical Science, 2013
The oxygen electrode reaction at the interface gold/yttria stabilized zirconia (YSZ) was investigated at moderate temperatures of 500 and 600°C under ambient air condition, with emphasis put on the comparative analysis for effect of anodic and cathodic ...
Guangwei Wang, Heping Li, Yuanjian Xu, Liping Xu, Lei Zhang   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Influence of Surface Roughness of YSZ on Polarization of Pt Electrode Deposited on the Electrolyte

International Journal of Electrochemical Science, 2013
The influence of surface roughness of YSZ on polarization of Pt electrode deposited on the electrolyte was investigated in ambient air at 600°C, with emphasis put on the comparative analysis for the anodic and cathodic polarization of Pt electrode ...
Guangwei Wang, Heping Li, Yuanjian Xu, Liping Xu, Lei Zhang   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Chiral Symmetry transition in the Linear Sigma Model with quarks: Counting effective QCD degrees of freedom from low to high temperature

, 2016
We use the linear sigma model coupled to quarks, together with a plausible location of the critical end point (CEP), to study the chiral symmetry transition in the QCD phase diagram. We compute the effective potential at finite temperature and density up
Ayala, Alejandro, Castano-Yepes, Jorge David, Cobos-Martinez, J. J., Hernandez-Ortiz, Saul, Mizher, Ana Julia, Raya, Alfredo   +5 more
core   +1 more source