Results 221 to 230 of about 14,792,115 (254)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Microsecond X-ray reflectometry. [PDF]

J Appl Crystallogr
Haberl M, Eder M, Pfeiler E, Schumi-Mareček D, Bertram F, Mikulík P, Kowarik S.   +6 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Picosecond Dynamics of Selective Ablation in a Ni/Al Multilayer Thin Film Induced by a Femtosecond Laser Pulse. [PDF]

Nanomaterials (Basel)
Ashitkov SI, Komarov PS, Struleva EV, Ovchinnikov MA, Sitnikov DS.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Direct Observation of Topologically Enhanced Interfacial Miscibility in Ring-Linear Polymers. [PDF]

ACS Cent Sci
Kim SE, Kim D, Park SH, Kong TY, Lee JH, Kim KT, Kim SY.   +6 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Broadband extreme ultraviolet zeroth order scatterometry for nanostructure metrology. [PDF]

Nat Commun
Corazza F, Kechaoglou E, Guery L, Nie Z, Phadke P, Lehmann CS, Bliem R, Kraus PM.   +7 more
europepmc   +1 more source

Enhanced Quantum Dot Light Emission at Telecom Wavelengths on Metallic Mirrors. [PDF]

Nanomaterials (Basel)
Kaur R, Alkaales M, Benyoucef M.
europepmc   +1 more source

Evaluation of Shack-Hartmann wavefront sensing artifacts due to reflectivity variations across thick layered samples using the discrete Fourier transform. [PDF]

Biomed Opt Express
Sahoo PK, Raj M R A, Akondi V.
europepmc   +1 more source