Results 91 to 100 of about 10,698,248 (292)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
University High Highlights 11/1/1961 [PDF]
, 1961 This is the student newspaper from University High School, the high school that was on the campus of Western Michigan University, then called University High Highlights, in ...
, University High School
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
University High Highlights 2/19/1965 [PDF]
, 1965 This is the student newspaper from University High School, the high school that was on the campus of Western Michigan University, then called University High Highlights, in ...
, University High School
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
University High Highlights 5/25/1960 [PDF]
, 1960 This is the student newspaper from University High School, the high school that was on the campus of Western Michigan University, then called University High Highlights, in ...
, University High School
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
State Highlights 12/15/1954 [PDF]
, 1953 This is the student newspaper from Western State High School, the high school that was on the campus of Western Michigan University, then called State Highlights, in ...
, Western State High School
core +6 more sources
Frontiers in Reproductive HealthBackgroundPrimary dysmenorrhea is a common gynecological problem characterized by recurrent, periodical, and cramping pain in the lower abdomen that occurs before or during menstruation, usually without pelvic disease.
Bekan Gudata Gindaba +4 more
doaj +1 more source