Results 121 to 130 of about 10,661,271 (293)

State Highlights 3/29/1950 [PDF]

open access: yes, 1950
This is the student newspaper from Western State High School, the high school that was on the campus of Western Michigan University, then called State Highlights, in ...
, Western State High School
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

State Highlights 3/22/1940 [PDF]

open access: yes, 1940
This is the student newspaper from Western State High School, the high school that was on the campus of Western Michigan University, then called State Highlights, in ...
, Western State High School
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

State Highlights 4/7/1954 [PDF]

open access: yes, 1954
This is the student newspaper from Western State High School, the high school that was on the campus of Western Michigan University, then called State Highlights, in ...
, Western State High School
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

State Highlights 5/11/1955 [PDF]

open access: yes, 1955
This is the student newspaper from Western State High School, the high school that was on the campus of Western Michigan University, then called State Highlights, in ...
, Western State High School
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Informing Language Teaching through Language Learning Informando la enseñanza de lenguas a través del aprendizaje de lenguas

open access: yesProfile: Issues in Teachers' Professional Development, 2006
Teacher development texts generally work from the assumption that teachers have a number of colleagues and mentors available to share ideas with and seek guidance from.
Shelley A Spencer
doaj  

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